Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia
文献类型：期刊论文
| 作者 | Xiu, Meihong6; Fan, Yong5; Liu, Qinqin5; Chen, Song6; Wu, Fengchun2,3,4; Zhang, Xiangyang1
|
| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
 |
| 出版日期 | 2023-10-01 |
| 卷号 | 23期号:4页码:7 |
| 关键词 | Schizophrenia Glucose Hippocampal subfields Cognitive function |
| ISSN号 | 1697-2600 |
| DOI | 10.1016/j.ijchp.2023.100402 |
| 通讯作者 | Wu, Fengchun(13580380071@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Previous studies have indicated that glucose metabolism and altered hippocampal structure and function play a pivotal role in cognitive deficits in schizophrenia (SZ). This study was designed to explore the inter-relationship between glucose metabolism, hippocampal subfield volume, and cognitive function in the antipsychoticsnaive first episode (ANFE) SZ patients. Methods: We chose the fasting insulin, glucose, and insulin resistance (HOMA-IR) index as biomarkers of glucose metabolism. Cognitive function was assessed by the MATRICS Consensus Cognitive Battery (MCCB). The hippocampal subfield volume, glucose metabolism biomarkers, and cognitive function were evaluated in 43 ANFE SZ and 29 healthy controls (HCs). Results: Compared with HCs, SZ patients had higher fasting blood glucose and insulin levels and HOMA-IR (all p < 0.05). Correlation analysis revealed that category fluency performance was positively associated with fasting glucose level. Fasting insulin or HOMA-IR was positively associated with the hippocampal subfield volume in patients (all p<0.05). Moreover, the spatial span index score was associated with the volume of the right presubiculum, subiculum, and right hippocampal tail. In addition, multiple regression analysis found that the interaction effects of insulin x right fimbria or insulin x left fimbria were independent predictors of the MCCB total score. Conclusions: Our findings suggest that abnormal glucose metabolism and cognitive decline occur in the early stage of SZ. The interaction between abnormal glucose metabolism and hippocampal subfields was associated with cognitive functions in SZ. |
| 收录类别 | SCI |
| WOS关键词 | INSULIN-RESISTANCE ; CATEGORY FLUENCY ; DYSFUNCTION ; SEGMENTATION ; ASSOCIATION ; VIVO ; IMPAIRMENT ; DECLINE ; DIETARY ; MRI |
| 资助项目 | Science and Technology Program of Guangzhou[202206060005] ; Science and Technology Program of Guangzhou[202201010093] ; Science and Technology Program of Guangzhou[SL2022A03J01489] ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project[2021B1515020064] ; Medical Science and Technology Research Foundation of Guangdong[A2023224] ; Health Science and Technology Program of Guangzhou[20231A010036] ; Scientific research project of traditional Chinese medicine of Guangdong[20211306] ; Guangzhou Municipal Key Discipline in Medicine ; Guangzhou High-level Clinical Key Specialty ; Guangzhou Research-oriented Hospital |
| WOS研究方向 | Psychology |
| 语种 | 英语 |
| WOS记录号 | WOS:001165002800001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | Science and Technology Program of Guangzhou ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project ; Medical Science and Technology Research Foundation of Guangdong ; Health Science and Technology Program of Guangzhou ; Scientific research project of traditional Chinese medicine of Guangdong ; Guangzhou Municipal Key Discipline in Medicine ; Guangzhou High-level Clinical Key Specialty ; Guangzhou Research-oriented Hospital |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47174]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wu, Fengchun; Zhang, Xiangyang |
| 作者单位 | 1.Inst Psychol, Chinese Acad Sci, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China 3.Guangzhou Med Univ, Dept Biomed Engn, Guangzhou, Peoples R China 4.Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, Guangzhou, Peoples R China 5.Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 6.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiu, Meihong,Fan, Yong,Liu, Qinqin,et al. Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(4):7. |
| APA | Xiu, Meihong,Fan, Yong,Liu, Qinqin,Chen, Song,Wu, Fengchun,&Zhang, Xiangyang.(2023).Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(4),7. |
| MLA | Xiu, Meihong,et al."Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.4(2023):7. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。