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Prevalence and risk factors of anxiety symptoms in first-episode and drug-na?ve major depressive disorder patients with metabolic syndrome

文献类型：期刊论文

作者Liu, Jizhou5; Yang, Yonglan5; Zhang, Yanjiang5; Wang, Haifeng5; Wei, Wenjian5; Lang, Xiaoe4; Zhang, Xiangyang1,2,3
刊名EUROPEAN JOURNAL OF PSYCHIATRY
出版日期2023-10-01
卷号37期号:4页码:7
关键词Anxiety symptoms Major depressive disorder First episode and drug naive (FEDN) Metabolic syndrome Risk factor
ISSN号0213-6163
DOI10.1016/j.ejpsy.2023.07.001
通讯作者Zhang, Xiangyang(zhangxyxyx@sina.com)
英文摘要Background and objectives: Patients with major depressive disorder (MDD) have high comorbidity with metabolic syndrome (MetS), although anxiety is prevalent comorbidity in MDD patients. However, there is no study on anxiety symptoms (AS) in MDD patients with MetS. Therefore, we aimed to identify the prevalence and risk factors of AS in patients with MetS who experienced a first-episode and drug naive (FEDN) of MDD. Methods: In this cross-sectional study, 1718 FEDN of MDD outpatients with MetS were included. Sociodemographic data, clinical characteristics, suicidal attempts, and physical and biochemical parameters were collected. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Positive and Negative Syndrome Scale (PANSS) positive subscale were performed to detect the AS. Multiple linear regression analysis was used to analyze the correlation. Results: The prevalence of AS in MDD patients with MetS was 85.96%, which was 1.79 times greater than that in patients with MDD alone (P<0.05). MDD patients with MetS had a greater rate of attempted suicide, a higher HAMD total score, and a higher diastolic blood pressure than MDD patients without AS (P<0.05). Their combination could distinguish AS in MDD patients. Moreover, HAMD score, thyroid-stimulating hormone (TSH) levels, PANSS positive score, and suicide attempts were related to HAMA scores in MDD patients with comorbid MetS (P<0.05). Conclusion: There is a significant frequency of AS in MDD patients with MetS. Multiple clinical indicators and metabolic markers are associated with AS in patients with MDD and MetS. (c) 2023 The Authors. Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Psiquiatria y Salud Mental.
收录类别SCI
WOS关键词ANXIOUS DEPRESSION ; COMORBID ANXIETY ; METAANALYSIS ; HYPERTENSION ; ASSOCIATION ; CHINA
资助项目Chinese National Programs for Brain Science and Brain-like Intelligence Technology[2021ZD0202102]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001164999700001
出版者ELSEVIER ESPANA SLU
资助机构Chinese National Programs for Brain Science and Brain-like Intelligence Technology
源URL[http://ir.psych.ac.cn/handle/311026/47184]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Shanxi Med Univ, Hosp 1, Dept Psychiat, Clin Med Coll 1, Taiyuan 030000, Peoples R China
5.2nd Peoples Hosp Honghe Hani & Yi Autonomous Prefe, Dept Clin Psychol, Jianshui 654399, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jizhou,Yang, Yonglan,Zhang, Yanjiang,et al. Prevalence and risk factors of anxiety symptoms in first-episode and drug-na?ve major depressive disorder patients with metabolic syndrome[J]. EUROPEAN JOURNAL OF PSYCHIATRY,2023,37(4):7.
APA Liu, Jizhou.,Yang, Yonglan.,Zhang, Yanjiang.,Wang, Haifeng.,Wei, Wenjian.,...&Zhang, Xiangyang.(2023).Prevalence and risk factors of anxiety symptoms in first-episode and drug-na?ve major depressive disorder patients with metabolic syndrome.EUROPEAN JOURNAL OF PSYCHIATRY,37(4),7.
MLA Liu, Jizhou,et al."Prevalence and risk factors of anxiety symptoms in first-episode and drug-na?ve major depressive disorder patients with metabolic syndrome".EUROPEAN JOURNAL OF PSYCHIATRY 37.4(2023):7.

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来源：心理研究所

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