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Prevalence and risk factors for abnormal glucose metabolism in first-episode and drug-na?ve major depressive disorder outpatients with comorbid anxiety: A cross-sectional study from a large sample of the Chinese Han population

文献类型：期刊论文

作者Xu, Huixue3,4; Liu, Liyan3,4; Yang, Qian1; Wang, Xin3,4; Li, Zejun3,4; Liu, Tieqiao3,4; Zhang, Xiangyang2
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2024-03-15
卷号349页码:400-406
ISSN号0165-0327
关键词Major depressive disorder Glucose disturbances First -episode drug-naive Anxiety
DOI10.1016/j.jad.2024.01.014
通讯作者Liu, Tieqiao(liutieqiao123@csu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Both abnormal glucose metabolism and anxiety have been reported to be common in major depressive disorder (MDD). However, few studies have explored glucose disturbances in first -episode and drugnaive (FEDN) MDD patients with anxiety. The purpose of this study was to examine the prevalence and risk factors of glucose disturbance in FEND MDD patients comorbid with anxiety. Methods: 1718 FEDN MDD patients were included in this study. The positive subscale of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD) were used to measure psychotic, anxiety and depressive symptoms respectively. Sociodemographic and biochemical indicators were also collected. Results: The prevalence of glucose disorders in MDD patients combined with anxiety was 15.7 %, significantly higher than in MDD patients without anxiety symptoms (7.1 %). Glucose disturbances were associated with HAMD score, HAMA score, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin (TGAb), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), suicide attempts, and psychotic symptoms. Further logistic regression showed that illness duration, TSH, TGAb, and TPOAb levels were correlates of glucose disturbances in MDD patients with anxiety. Limitations: No causal relationship could be drawn due to the cross-sectional design. Conclusions: Our findings suggest that TSH, TGAb and TPOAb may be promising biomarkers of glucose disturbances in MDD comorbid with anxiety, suggesting the importance of regular assessment of thyroid function parameters for abnormal glucose metabolism prevention.
收录类别SCI
WOS关键词CLINICAL CHARACTERISTICS ; DIABETES-MELLITUS ; BIPOLAR DISORDER ; MENTAL-DISORDERS ; ASSOCIATION ; MECHANISMS ; MORTALITY ; COMMUNITY ; CHILDREN ; DISEASE
资助项目Provincial Natural Science Foundation of Hunan[2020JJ4795] ; Hunan Provincial Innovation Foundation for Postgraduate[CX20220341] ; Fundamental Research Funds for the Central Universities of Central South University[2022ZZTS0259]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:001164747000001
资助机构Provincial Natural Science Foundation of Hunan ; Hunan Provincial Innovation Foundation for Postgraduate ; Fundamental Research Funds for the Central Universities of Central South University
源URL[http://ir.psych.ac.cn/handle/311026/47200]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liu, Tieqiao; Zhang, Xiangyang
作者单位1.Zhongshan City Peoples Hosp, Dept Psychol, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
4.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Huixue,Liu, Liyan,Yang, Qian,et al. Prevalence and risk factors for abnormal glucose metabolism in first-episode and drug-na?ve major depressive disorder outpatients with comorbid anxiety: A cross-sectional study from a large sample of the Chinese Han population[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,349:400-406.
APA Xu, Huixue.,Liu, Liyan.,Yang, Qian.,Wang, Xin.,Li, Zejun.,...&Zhang, Xiangyang.(2024).Prevalence and risk factors for abnormal glucose metabolism in first-episode and drug-na?ve major depressive disorder outpatients with comorbid anxiety: A cross-sectional study from a large sample of the Chinese Han population.JOURNAL OF AFFECTIVE DISORDERS,349,400-406.
MLA Xu, Huixue,et al."Prevalence and risk factors for abnormal glucose metabolism in first-episode and drug-na?ve major depressive disorder outpatients with comorbid anxiety: A cross-sectional study from a large sample of the Chinese Han population".JOURNAL OF AFFECTIVE DISORDERS 349(2024):400-406.

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来源：心理研究所

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