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A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model

文献类型：期刊论文

作者Fu, Chong-Lei2,3; Dong, Bo-Cheng3; Jiang, Xi3; Li, Dan1
刊名HELIYON
出版日期2024-01-30
卷号10期号:2页码:11
关键词Cell therapy iPSC Midbrain organoids Parkinson 's disease
DOI10.1016/j.heliyon.2024.e24234
通讯作者Li, Dan(jyao@mail.tsinghua.edu.cn)
英文摘要Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra and loss of DA transmission in the striatum, thus making cell transplantation an effective treatment strategy. Here, we develop a cellular therapy based on induced pluripotent stem cell (iPSC)-derived midbrain organoids. By transplanting midbrain organoid cells into the striatum region of a 6-OHDA-lesioned PD mouse model, we found that the transplanted cells survived and highly efficiently differentiated into DA neurons. Further, using a dopamine sensor, we observed that the differentiated human DA neurons could efficiently release dopamine and were integrated into the neural network of the PD mice. Moreover, starting from four weeks after transplantation, the motor function of the transplanted mice could be significantly improved. Therefore, cell therapy based on iPSC-derived midbrain organoids can be a potential strategy for the clinical treatment of PD.
收录类别SCI
WOS关键词DOPAMINE ; NEURONS
资助项目National Natural Science Foundation of China[31830038] ; National Natural Science Foundation of China[31771482] ; Beijing Municipal Natural Science Foundation[Z210011]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者CELL PRESS
WOS记录号WOS:001163958900001
资助机构National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation
源URL[http://ir.psych.ac.cn/handle/311026/47215]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Dan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Shandong First Med Univ & Shandong Acad Med Sci, Shandong Inst Brain Sci & Brain Inspired Res, Jinan 250117, Peoples R China
3.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, State Key Lab Membrane Biol, IDG McGovern Inst Brain Res,Sch Life Sci, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Chong-Lei,Dong, Bo-Cheng,Jiang, Xi,et al. A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model[J]. HELIYON,2024,10(2):11.
APA Fu, Chong-Lei,Dong, Bo-Cheng,Jiang, Xi,&Li, Dan.(2024).A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model.HELIYON,10(2),11.
MLA Fu, Chong-Lei,et al."A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model".HELIYON 10.2(2024):11.

入库方式： OAI收割

来源：心理研究所

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