中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility

文献类型：期刊论文

作者Wei, Mengping8,9,10; Yang, Lei8,9,10; Su, Feng7; Liu, Ying5,6; Zhao, Xinyi8,9,10; Luo, Lin8,9,10; Sun, Xinyue8,9,10; Liu, Sen8,9,10; Dong, Zhaoqi10; Zhang, Yong2,3,4
刊名PROGRESS IN NEUROBIOLOGY
出版日期2024-02-01
卷号233页码:17
ISSN号0301-0082
关键词AMPA receptors ABHD6 Endocytosis Synaptic plasticity Learning flexibility
DOI10.1016/j.pneurobio.2023.102559
通讯作者Wei, Mengping(weimengping@ccmu.edu.cn) ; Liang, Jing(liangj@psych.ac.cn) ; Zhang, Chen(czhang@ccmu.edu.cn)
英文摘要Trafficking of alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors (AMPARs), mediated by AMPAR interacting proteins, enabled neurons to maintain tuning capabilities at rest or active state. alpha/beta-Hydrolase domain-containing 6 (ABHD6), an endocannabinoid hydrolase, was an AMPAR auxiliary subunit found to negatively regulate the surface delivery of AMPARs. While ABHD6 was found to prevent AMPAR tetramerization in endoplasmic reticulum, ABHD6 was also reported to localize at postsynaptic site. Yet, the role of ABHD6 interacting with AMPAR at postsynaptic site, and the physiological significance of ABHD6 regulating AMPAR trafficking remains elusive. Here, we generated the ABHD6 knockout (ABHD6KO) mice and found that deletion of ABHD6 selectively enhanced AMPAR-mediated basal synaptic responses and the surface expression of postsynaptic AMPARs. Furthermore, we found that loss of ABHD6 impaired hippocampal long-term depression (LTD) and synaptic downscaling in hippocampal synapses. AMPAR internalization assays revealed that ABHD6 was essential for neuronal activity-dependent endocytosis of surface AMPARs, which is independent of ABHD6's hydrolase activity. The defects of AMPAR endocytosis and LTD are expressed as deficits in learning flexibility in ABHD6KO mice. Collectively, we demonstrated that ABHD6 is an endocytic accessory protein promoting AMPAR endocytosis, thereby contributes to the formation of LTD, synaptic downscaling and reversal learning.
收录类别SCI
WOS关键词LONG-TERM DEPRESSION ; SERINE HYDROLASE ABHD6 ; ORBITOFRONTAL CORTEX ; BEHAVIORAL FLEXIBILITY ; VISUAL-DISCRIMINATION ; PROTEIN-SYNTHESIS ; MOUSE MODEL ; HIPPOCAMPAL ; ACTIVATION ; GLUR2
资助项目National Natural Science Foundation of China[81925011] ; National Natural Science Foundation of China[92149304] ; National Natural Science Foundation of China[32170954] ; National Natural Science Foundation of China[32100763] ; Key -Area Research and Development Program of Guangdong Province[2019B030335001] ; Youth Beijing Scholars Program[015] ; Young Elite Scientists Sponsorship Program by CAST[2022QNRC001]
WOS研究方向Neurosciences & Neurology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:001162318100001
资助机构National Natural Science Foundation of China ; Key -Area Research and Development Program of Guangdong Province ; Youth Beijing Scholars Program ; Young Elite Scientists Sponsorship Program by CAST
源URL[http://ir.psych.ac.cn/handle/311026/47218]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wei, Mengping; Liang, Jing; Zhang, Chen
作者单位1.Nanjing Univ, Model Anim Res Ctr, Med Sch, Minist Educ Key Lab Model Anim Dis Study, Nanjing 210032, Peoples R China
2.Peking Univ, McGovern Inst Brain Res PKU, Natl Hlth Commiss PR China, IDG, Beijing 100083, Peoples R China
3.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ China, Beijing 100083, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
7.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
8.Chinese Inst Brain Res, Beijing 102206, Peoples R China
9.State Key Lab Neurol & Oncol Drug Dev, Nanjing 210000, Peoples R China
10.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Sch Basic Med Sci, Beijing Key Lab Neural Regenerat & Repair, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Mengping,Yang, Lei,Su, Feng,et al. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility[J]. PROGRESS IN NEUROBIOLOGY,2024,233:17.
APA Wei, Mengping.,Yang, Lei.,Su, Feng.,Liu, Ying.,Zhao, Xinyi.,...&Zhang, Chen.(2024).ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility.PROGRESS IN NEUROBIOLOGY,233,17.
MLA Wei, Mengping,et al."ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility".PROGRESS IN NEUROBIOLOGY 233(2024):17.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。