Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
文献类型：期刊论文
| 作者 | Huang, Huan5; Chen, Cheng5; Rong, Bei5; Zhou, Yuan4 ; Yuan, Wei3; Peng, Yunlong3; Liu, Zhongchun5; Wang, Gaohua2,5; Wang, Huiling1,5
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| 刊名 | BRAIN IMAGING AND BEHAVIOR
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| 出版日期 | 2024-02-13 |
| 页码 | 11 |
| 关键词 | Anterior cingulate cortex Schizophrenia Resting-state functional connectivity. |
| ISSN号 | 1931-7557 |
| DOI | 10.1007/s11682-024-00863-0 |
| 通讯作者 | Wang, Huiling(hlwang@whu.edu.cn) |
| 英文摘要 | The anterior cingulate cortex (ACC) is a heterogeneous region of the brain's limbic system that regulates cognitive and emotional processing, and is frequently implicated in schizophrenia. This study aims to characterize resting-state functional connectivity (rsFC) profiles of three subregions of ACC in patients with first-episode schizophrenia and healthy controls. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were collected from 60 first-episode schizophrenia (FES) patients and 60 healthy controls (HC), and the subgenual ACC (sgACC), pregenual ACC (pgACC), and dorsal ACC (dACC) were selected as seed regions from the newest automated anatomical labeling atlas 3 (AAL3). Seed-based rsFC maps for each ACC subregion were generated and compared between the two groups. The results revealed that compared to the HC group, the FES group showed higher rsFC between the pgACC and bilateral lateral orbitofrontal cortex (lOFC), and lower rsFC between the dACC and right posterior OFC (pOFC), the medial prefrontal gyrus (MPFC), and the precuneus cortex (PCu). These findings point to a selective functional dysconnectivity of pgACC and dACC in schizophrenia and provide more accurate information about the functional role of the ACC in this disorder. |
| 收录类别 | SCI |
| WOS关键词 | VON ECONOMO NEURONS ; PREFRONTAL CORTEX ; DOSE EQUIVALENTS ; BRAIN STRUCTURE ; SALIENCE ; NETWORK ; DYSCONNECTIVITY ; HYPOTHESIS ; PSYCHOSIS ; DISCONNECTION |
| 资助项目 | Fundamental Research Funds for the Central Universities |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001160982700002 |
| 出版者 | SPRINGER |
| 资助机构 | Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47197]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 通讯作者 | Wang, Huiling |
| 作者单位 | 1.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China 2.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China 3.Yidu Peoples Hosp, Dept Psychiat, Yidu 443300, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.Wuhan Univ, Dept Psychiat, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Huan,Chen, Cheng,Rong, Bei,et al. Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia[J]. BRAIN IMAGING AND BEHAVIOR,2024:11. |
| APA | Huang, Huan.,Chen, Cheng.,Rong, Bei.,Zhou, Yuan.,Yuan, Wei.,...&Wang, Huiling.(2024).Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.BRAIN IMAGING AND BEHAVIOR,11. |
| MLA | Huang, Huan,et al."Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia".BRAIN IMAGING AND BEHAVIOR (2024):11. |
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来源：心理研究所
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