Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy
文献类型：期刊论文
| 作者 | Jin, Yushen4 ; Cheng, Zhongquan3; Yuan, Zhu3; Du, Yang2; Tian, Jie2; Shao, Bing1,4
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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| 出版日期 | 2024 |
| 卷号 | 19页码:189-208 |
| ISSN号 | 1178-2013 |
| 关键词 | porous hollow structure magnetic particle imaging fluorescence imaging synergistic treatment theranostics |
| DOI | 10.2147/IJN.S428687 |
| 通讯作者 | Shao, Bing(shaobingch@sina.com) |
| 英文摘要 | Purpose: Liver cancer is considered as the third leading cause of cancer-related deaths, with hepatocellular carcinoma (HCC) accounting for approximately 90% of liver cancers. Improving the treatment of HCC is a serious challenge today. The primary objective of this study was to construct SP94-Fe3O4@ICG&DOX nanoparticles and investigate their potential diagnosis and treatment effect benefits on HCC.Methods: Firstly, we synthesized and characterized SP94-Fe3O4@ICG&DOX nanoparticles and confirmed their in vitro release behavior, photothermal and photodynamic performance. Moreover, the in vivo imaging capability was also observed. Finally, the inhibitory effects on Hepa1-6 in vitro and in vivo were observed as well as biosafety.Results: SP94-Fe3O4@ICG&DOX nanoparticles have a size of similar to 22.1 nm, with an encapsulation efficiency of 45.2% for ICG and 42.7% for DOX, showing excellent in vivo MPI and fluorescence imaging capabilities for precise tumor localization, and synergistic photo-chemotherapy (pH-and thermal-sensitive drug release) against tumors under irradiation. With the assistance of a fluorescence molecular imaging system or MPI scanner, the location and contours of the tumor were clearly visible. Under a constant laser irradiation (808 nm, 0.6 W/cm2) and a set concentration (50 mu g/mL), the temperature of the solution could rapidly increase to similar to 45 C-degrees, which could effectively kill the tumor cells. It could be effectively uptaken by HCC cells and significantly inhibit their proliferation under the laser irradiation (100% inhibition rate for HCC tumors). And most importantly, our nanoparticles exhibited favorable biocompatibility with normal tissues and cells.Conclusion: This versatile agent can serve as an intelligent and promising nanoplatform that integrates multiple accurate diagnoses, precise positioning of cancer tissue, and effective coordination with synergistic tumor photodynamic therapy. |
| WOS关键词 | CANCER ; PERFORMANCE ; DOXORUBICIN ; GRP78 |
| 资助项目 | National Natural Science Foundation of China[82072098] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| WOS记录号 | WOS:001145402800001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/55464]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Shao, Bing |
| 作者单位 | 1.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China 4.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,et al. Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19:189-208. |
| APA | Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,Du, Yang,Tian, Jie,&Shao, Bing.(2024).Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,19,189-208. |
| MLA | Jin, Yushen,et al."Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024):189-208. |
入库方式： OAI收割
来源：自动化研究所
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