Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale
文献类型：期刊论文
| 作者 | Fan, Yao-Yue1,2,3,4; Zhang, Xin-Ru1,2; Zheng, Cheng-Yu1; Li, Ying3; Yue, Jian-Min1,2,3
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2024-02-15 |
| 卷号 | 152页码:8 |
| 关键词 | Hedyosmum orientale Natural products Guaian-8,12-olide Structure elucidation Anti-inflammatory activity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2024.133841 |
| 通讯作者 | Fan, Yao-Yue(yyfan@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Eleven previously undescribed guaian-8,12-olides, hedyolides A -K (1-11) featuring a characteristic 5,7,5 -fused tricyclic and possessing different degrees of unsaturation and oxygen substitution patterns, were isolated from the leaves and twigs of Hedyosmum orientale. In particular, compounds 6 and 10 are rare chlorinated guaianolides of plant origin. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis, quantum chemical calculations, DP4+ probability, and single -crystal X-ray diffraction. All compounds exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values ranging from 1.22 to 6.51 mu M. |
| WOS关键词 | SESQUITERPENE ; LACTONE |
| 资助项目 | National Natural Science Foundation of China[82122062] ; National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[KFJ-BRP-008] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001164792900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309557]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Chem Biol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yao-Yue,Zhang, Xin-Ru,Zheng, Cheng-Yu,et al. Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale[J]. TETRAHEDRON,2024,152:8. |
| APA | Fan, Yao-Yue,Zhang, Xin-Ru,Zheng, Cheng-Yu,Li, Ying,&Yue, Jian-Min.(2024).Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale.TETRAHEDRON,152,8. |
| MLA | Fan, Yao-Yue,et al."Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale".TETRAHEDRON 152(2024):8. |
入库方式： OAI收割
来源：上海药物研究所
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