中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory

文献类型：期刊论文

作者Zhang, Hui1; Hu, Ke1; Lu, Yumeng1; Xu, Zhijian2; Chen, Gege1; Yu, Dandan2; Gao, Xuejie1; Feng, Qilin1; Jia, Xinyan1; Xu, Li1
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
出版日期2024-01-25
卷号127页码:14
关键词Multiple myeloma M1 macrophages Th1 cells Immunomodulatory
ISSN号1567-5769
DOI10.1016/j.intimp.2023.111446
通讯作者Li, Bo(boli@simm.ac.cn) ; Zhu, Weiliang(wlzhu@simm.ac.cn) ; Shi, Jumei(shijumei@tongji.edu.cn)
英文摘要Multiple myeloma (MM) is an incurable and recurrent malignancy characterized by abnormal plasma cell proliferation. There is an urgent need to develop effective drugs in MM. DCZ0825 is a small molecule compound derived from pterostilbene with direct anti-myeloma activity and indirect immune-killing effects though reversal of the immunosuppression. DCZ0825 inhibits the activity and proliferation of MM cells causing no significant toxicity to normal cells. Using flow cytometry, this study found that DCZ0825 induced caspase-dependent apoptosis in MM cells and arrested the cell cycle in the G2/M phase by down-regulating CyclinB1, CDK1 and CDC25. Moreover, DCZ0825 up-regulated IRF3 and IRF7 to increase IFN-gamma, promoting M2 macrophages to transform into M1 macrophages, releasing the immunosuppression of CD4T cells and stimulated M1 macrophages and Th1 cells to secrete more INF-gamma to form immune killing effect on MM cells. Treatment with DCZ0825 resulted in an increased proportion of positive regulatory cells such as CD4T, memory T cells, CD8T, and NK cells, with downregulation of the proportion of negative regulatory cells such as Treg cells and MDSCs. In conclusion, DCZ0825 is a novel compound with both antitumor and immunomodulatory activity.
WOS关键词REGULATORY T-CELLS ; MULTIPLE-MYELOMA ; APOPTOSIS ; CANCER ; DIAGNOSIS ; IMMUNITY ; TARGETS ; DEATH
资助项目National Natural Science Foundation of China[81971529] ; National Natural Science Foundation of China[82000220] ; National Natural Science Foundation of China[82170200] ; National Natural Science Foundation of China[82070224] ; National Natural Science Foundation of China[22077131] ; Chinese Pharmaceutical Association-Yiling Biopharmaceutical Innovation Project[CPAYLJ201908] ; State Key Laboratory of Natural and Biomimetic Drugs[K202108]
WOS研究方向Immunology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001164868900001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309563]  
专题新药研究国家重点实验室
通讯作者Li, Bo; Zhu, Weiliang; Shi, Jumei
作者单位1.Tongji Univ, Shanghai East Hosp, Dept Hematol, Sch Med, Shanghai 200120, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Tongji Univ, Shanghai Peoples Hosp 10, Dept Hematol, Sch Med, Shanghai 200072, Peoples R China
4.Tongji Univ, Shanghai East Hosp, Shanghai Inst Mat Med, Drug Discovery & Design Ctr,Sch Med, 150 Jimo Rd, Shanghai 200120, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Hui,Hu, Ke,Lu, Yumeng,et al. A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,127:14.
APA Zhang, Hui.,Hu, Ke.,Lu, Yumeng.,Xu, Zhijian.,Chen, Gege.,...&Shi, Jumei.(2024).A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory.INTERNATIONAL IMMUNOPHARMACOLOGY,127,14.
MLA Zhang, Hui,et al."A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory".INTERNATIONAL IMMUNOPHARMACOLOGY 127(2024):14.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。