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Stachyose with effect on anti-angiogenic activity from Salvia yunnanensis

文献类型：期刊论文

作者Xu, Yangyang1,2; He, Fei3; Jin, Can2; Su, Juan3; Ding, Kan2,3
刊名JOURNAL OF FUNCTIONAL FOODS
出版日期2024
卷号112页码:10
关键词Salvia yunnanensis Stachyose Anti-angiogenic activity Galectin-3
ISSN号1756-4646
DOI10.1016/j.jff.2023.105971
通讯作者He, Fei(hefei1@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要Salvia yunnanensis is a traditional Chinese medicine for promoting blood circulation and eliminating blood stasis. Previous researches reported that Tanshinone IIA from Salvia yunnanensis had anti-angiogenic effect, however, whether its carbohydrates with similar effect is unknown. Here, we showed that a stachyose (Sta) from Salvia yunnanensis was purified by DEAE SepharoseTM Fast Flow anion-exchange chromatography and Bio-Gel P-2 gel permeation chromatography. Structure analyses suggested that Sta was tetrasaccharide as alpha-Gal-(1 -> 6)-alpha-Gal- (1 -> 6)-alpha-Glc-(1 -> 2)-beta-Fru. Further sulfated Sta was made and the degree of sulfate substitution was measured as 0.98. Bioactivity studies showed that Sta might block human microvascular endothelial cells tube formation in vitro and in vivo without significant cytotoxicity. Mechanism study suggested that Sta might bind to Galectin-3 (KD: 5.777E- 6 ) and inhibit its expression to block angiogenesis linked to VEGFR/FAK and PDGFR/AKT/ERK signaling. Evidence also supported that Sta might be a potential compound for developing stachyose as an antiangiogenesis functional food.
WOS关键词STRUCTURAL-CHARACTERIZATION ; CANCER-CELL ; PECTIC OLIGOSACCHARIDE ; GALECTIN-3 ; DITERPENOIDS ; OPTIMIZATION ; ELUCIDATION ; DERIVATIVES ; METASTASIS ; MODULATION
WOS研究方向Food Science & Technology ; Nutrition & Dietetics
语种英语
WOS记录号WOS:001157988400001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309566]  
专题中国科学院上海药物研究所
通讯作者He, Fei; Ding, Kan
作者单位1.Zhongshan Hosp Tradit Chinese Med, Pharmacol Lab, Zhongshan 528401, Guangdong, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, Glycochemistry & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yangyang,He, Fei,Jin, Can,et al. Stachyose with effect on anti-angiogenic activity from Salvia yunnanensis[J]. JOURNAL OF FUNCTIONAL FOODS,2024,112:10.
APA Xu, Yangyang,He, Fei,Jin, Can,Su, Juan,&Ding, Kan.(2024).Stachyose with effect on anti-angiogenic activity from Salvia yunnanensis.JOURNAL OF FUNCTIONAL FOODS,112,10.
MLA Xu, Yangyang,et al."Stachyose with effect on anti-angiogenic activity from Salvia yunnanensis".JOURNAL OF FUNCTIONAL FOODS 112(2024):10.

入库方式： OAI收割

来源：上海药物研究所

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