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Chinese Academy of Sciences Institutional Repositories Grid
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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin

文献类型：期刊论文

作者Zhu, Yao1,2; Guo, Peng-Ju1,4; Ding, Ao-Xue1,2; Zheng, Liu1,2; Du, Gao-Xiang1,3; Chen, Tong1,3; Qin, Guo-Qinq; Hu, Xiang -Gang3; Wang, Wen-Qiong1; Xuan, Li -Jiang3,5
刊名PHYTOCHEMISTRY
出版日期2024-03-01
卷号219页码:10
关键词Valeriana jatamansi Jones Iridoids alpha-hemolysin Protective effects
ISSN号0031-9422
DOI10.1016/j.phytochem.2023.113962
通讯作者Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li -Jiang(ljxuan@simm.ac.cn)
英文摘要Thirteen previously undescribed iridoids (1-13), together with five known iridoids (14-18) were isolated from the roots and rhizomes of Valeriana jatamansi Jones. Their structures with absolute configurations were elucidated by analysis of MS, NMR, optical rotation and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their protective effects against alpha-hemolysininduced cell death in A549 cells. Compounds 14, 16 and 17 showed moderate protective effects, and compounds 15 and 18 showed weak protective effects.
WOS关键词ACYLATED IRIDOIDS ; SESQUITERPENOIDS ; PATHOPHYSIOLOGY ; EPIDEMIOLOGY ; SEVERITY ; TOXIN
资助项目Shanghai Municipal Science and Technology Major Project[TM202301L001]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001164250300001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/309584]  
专题新药研究国家重点实验室
通讯作者Wang, Wen-Qiong; Xuan, Li -Jiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yao,Guo, Peng-Ju,Ding, Ao-Xue,et al. Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin[J]. PHYTOCHEMISTRY,2024,219:10.
APA Zhu, Yao.,Guo, Peng-Ju.,Ding, Ao-Xue.,Zheng, Liu.,Du, Gao-Xiang.,...&Xuan, Li -Jiang.(2024).Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin.PHYTOCHEMISTRY,219,10.
MLA Zhu, Yao,et al."Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin".PHYTOCHEMISTRY 219(2024):10.

入库方式： OAI收割

来源：上海药物研究所

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