Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis
文献类型：期刊论文
| 作者 | Liu, Bo1; Han, Gui-Mei1; Wang, Dong-Xia1; Liu, Ding -Bin1; Liu, An -An1; Wang, Jing2; Xiao, Yu -Ling3,4,5,6; Yuan, Lin7; Kong, De -Ming1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2024 |
| 卷号 | 479页码:14 |
| ISSN号 | 1385-8947 |
| 关键词 | Atherosclerosis Reactive oxygen species Biomimetic nanoprobes In situ Ratiometric imaging |
| DOI | 10.1016/j.cej.2023.147515 |
| 通讯作者 | Wang, Jing(wangjing822@tmu.edu.cn) ; Xiao, Yu -Ling(xiaoyl@whu.edu.cn) ; Kong, De -Ming(kongdem@nankai.edu.cn) |
| 英文摘要 | Atherosclerosis (AS) is a major pathological factor to cardiovascular diseases, wherein reactive oxygen species (ROS) serve as the initiating link for the development of AS. However, direct and accurate assessment of ROS levels in AS plaque sites remains challenging. Herein, by embedding a ROS-responsive fluorescent small molecule (HDB with positive response or Cy7 with negative response) and a stable ROS-independent fluorescent dye CH1055 into red blood cell membrane (RBCM)-biomimetic liposomes, two biomimetic nanoprobes (R-Lipo@HDB/CH1055 and R-Lipo@Cy7/CH1055) were developed for indicating the existence of AS plaques and direct in situ ratiometric imaging of ROS at plaque sites. The fused RBCM endows the nanoprobes with attractive immune escape properties and the ability to accumulate at the AS sites. They not only can indicate the presence of plaques by the second near-infrared (NIR-II) fluorescence of CH1055, but also enable the accurate response to ROS levels through the upward or downward ratiometric fluorescence of HDB or Cy7 to CH1055, avoiding the interference of probe accumulation fluctuation or metabolism at the disease site and thus allowing for more accurate imaging compared to traditional monochromatic imaging. Via the specific responses of HDB and Cy7 to different species of ROS, we verified the upregulation of these ROS at the AS site using these two nanoprobes, and demonstrated their potential to assess the therapeutic effect of AS drugs. This study paves a feasible way to construct a ratiometric imaging platform using RBCM biomimetic liposomes to simultaneously encapsulate several functional molecules, achieving the disease diagnosis, pathological analysis and drug effect evaluation. |
| WOS关键词 | OXIDATIVE STRESS ; NANOPARTICLES ; DRUG ; NANOCARRIERS ; MECHANISMS ; LIPOSOMES ; HEART ; ROS |
| 资助项目 | National Key R & D Program of China[2019YFA0210103] ; National Natural Science Foundation of China[22074068] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE SA |
| WOS记录号 | WOS:001164774300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309590]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Jing; Xiao, Yu -Ling; Kong, De -Ming |
| 作者单位 | 1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 2.Tianjin Med Univ, Sch Med Lab, Coll Med Technol, Guangdong Rd, Tianjin 300203, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, State Key Lab Virol,Dept Cardiol, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 7.Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bo,Han, Gui-Mei,Wang, Dong-Xia,et al. Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis[J]. CHEMICAL ENGINEERING JOURNAL,2024,479:14. |
| APA | Liu, Bo.,Han, Gui-Mei.,Wang, Dong-Xia.,Liu, Ding -Bin.,Liu, An -An.,...&Kong, De -Ming.(2024).Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis.CHEMICAL ENGINEERING JOURNAL,479,14. |
| MLA | Liu, Bo,et al."Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis".CHEMICAL ENGINEERING JOURNAL 479(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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