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New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis

文献类型：期刊论文

作者Bu, Qing1; Yang, Min2; Yan, Xian-Yun1; Yao, Li-Gong2; Guo, Yue-Wei2,3,4,5,6; Liang, Lin-Fu1
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2022-12-01
卷号222页码:880-886
关键词Sarcophyton mililatensis Cembrane Macrocyclic diterpene Absolute configuration TNF ? inhibitor
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2022.09.210
文献子类Article
英文摘要A further study on the rarely reported soft coral Sarcophyton mililatensis disclosed five new flexible cembrane-type macrocyclic diterpenes sarcomililatols C-G (1-5) and two known analogues 6 and 7. The structures and absolute configurations of natural macrocyclic compounds 1-6 were established by the extensive spectroscopic analysis, X-ray diffraction analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT ECD) calculations, chemical reaction, and modified Mosher's method. In the bioassays, the macrocyclic diterpene 2 exhibited potent TNF-alpha inhibition (IC50 = 6.1 mu mol/L), which was better than the positive control dexametha-sone (IC50 = 8.7 mu mol/L), and no obvious cytotoxicity against RAW264.7 cells with CC50 values over 50 mu mol/L, indicating natural macrocyclic compound 2 could be served as a model compound to develop a new and pro-spective chemotype of an anti-inflammatory lead compound or drug candidate.
WOS关键词ABSOLUTE-CONFIGURATION
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000876942000001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309296]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei; Liang, Lin-Fu
作者单位1.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555, Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
3.Bohai rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China;
4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China;
5.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China;
6.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
推荐引用方式
GB/T 7714		 Bu, Qing,Yang, Min,Yan, Xian-Yun,et al. New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,222:880-886.
APA Bu, Qing,Yang, Min,Yan, Xian-Yun,Yao, Li-Gong,Guo, Yue-Wei,&Liang, Lin-Fu.(2022).New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,222,880-886.
MLA Bu, Qing,et al."New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222(2022):880-886.

入库方式： OAI收割

来源：上海药物研究所

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