Rh(III)-catalyzed twofold unsymmetrical CAH alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones
文献类型：期刊论文
| 作者 | Chen, Chao2,3; Zhang, Yi1,2; Shi, Chen2; Yang, Yaxi1,2,4 ; Zhou, Bing1,2,4,5
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2022-10-12 |
| 卷号 | 108页码:154141 |
| ISSN号 | 0040-4039 |
| 关键词 | C-H activation Twofold unsymmetrical functionalization Furoquinazolinone |
| DOI | 10.1016/j.tetlet.2022.154141 |
| 文献子类 | Article |
| 英文摘要 | Multiple functionalized arenes are irreplaceable part of numerous bioactive natural products and pharmaceuticals. Transition-metal-catalyzed direct unsymmetrical twofold or multiple C-H bonds functionalization was highly desirable but less explored. Herein, we have developed a Rh(III)-catalyzed unsymmetrical C-H alkenylation-annulation/amidation reaction with a O-bearing olefin-tethered arenes, enabling delivery of diverse furoquinazolinones in one step with broad substrate scope and good functional group tolerance. (C) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | C-H FUNCTIONALIZATION ; BOND ACTIVATION ; DIRECTING GROUP ; ARENES ; CONSTRUCTION ; OLEFINATION ; ARYLATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000965807400015 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309300]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yaxi; Zhou, Bing |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 3.Fudan Univ, Sch Pharm, Dept Med Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Chao,Zhang, Yi,Shi, Chen,et al. Rh(III)-catalyzed twofold unsymmetrical CAH alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones[J]. TETRAHEDRON LETTERS,2022,108:154141. |
| APA | Chen, Chao,Zhang, Yi,Shi, Chen,Yang, Yaxi,&Zhou, Bing.(2022).Rh(III)-catalyzed twofold unsymmetrical CAH alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones.TETRAHEDRON LETTERS,108,154141. |
| MLA | Chen, Chao,et al."Rh(III)-catalyzed twofold unsymmetrical CAH alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones".TETRAHEDRON LETTERS 108(2022):154141. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。