Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity
文献类型：期刊论文
| 作者 | Zhu, Huajian1; Wang, Jiang2 ; Lu, Yunfu2; Soloshonok, Vadim A.3,4; Lan, Lefu2; Xu, Jinyi1; Liu, Hong1,2
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2022-09-25 |
| 卷号 | 87期号:19页码:12900-12908 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.2c01481 |
| 文献子类 | Article |
| 英文摘要 | An operationally simple and convenient resolution method via Cu(II) complexes was reported, efficiently providing valuable enantiopure N,C-unprotected alpha-amino acids. This protocol features synthetically attractive yields and a stereochemical outcome, using a recyclable Schiff base ligand and inexpensive easily accessible metal copper salts. These novel Cu(II) complexes can be obtained in an enantiopure state by means of column chromatography or recrystallization. Furthermore, all the Cu(II) complexes were evaluated for their antibacterial activities. Among them, complexes (S,2S)-3a, (S,2S)-3g, and (S,2S)-3o showed significant antibacterial activities against Staphylococcus aureus Mu50. Further biological evaluation indicated that they were effective against most of Gram-positive bacteria. It is the first study on the biological activities of transition metal complexes with this type of proline-derived Schiff base ligand. |
| WOS关键词 | DYNAMIC KINETIC RESOLUTION ; ASYMMETRIC-SYNTHESIS ; S/R INTERCONVERSION ; NI(II) COMPLEXES ; ALPHA-ARYLATION ; DERACEMIZATION ; HOMOLOGATION ; AZLACTONES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000865307800001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309301]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lan, Lefu; Xu, Jinyi; Liu, Hong |
| 作者单位 | 1.China Pharmaceut Univ, Dept Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China; 2.Chinese Academ Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ Basque Country UPV EHU, Fac Chem, Dept Organ Chem 1, San Sebastian 20018, Spain; 4.Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain |
| 推荐引用方式 GB/T 7714 | Zhu, Huajian,Wang, Jiang,Lu, Yunfu,et al. Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity[J]. JOURNAL OF ORGANIC CHEMISTRY,2022,87(19):12900-12908. |
| APA | Zhu, Huajian.,Wang, Jiang.,Lu, Yunfu.,Soloshonok, Vadim A..,Lan, Lefu.,...&Liu, Hong.(2022).Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity.JOURNAL OF ORGANIC CHEMISTRY,87(19),12900-12908. |
| MLA | Zhu, Huajian,et al."Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity".JOURNAL OF ORGANIC CHEMISTRY 87.19(2022):12900-12908. |
入库方式： OAI收割
来源：上海药物研究所
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