Ursane and 24-Noroleanane-Type Triterpenoids with Anti-HIV Activity from the Twigs and Leaves of Antirhea chinensis
文献类型：期刊论文
| 作者 | Cui, Jiao-Jiao1,2; Han, Ying-Shan3; Zhou, Bin2,4; Yue, Jian-Min1,2,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2022-10 |
| 卷号 | 19期号:10页码:e202200716 |
| ISSN号 | 1612-1872 |
| 关键词 | Antirhea chinensis ursane triterpenoid 24-noroleanane triterpenoid anti-HIV activity |
| DOI | 10.1002/cbdv.202200716 |
| 文献子类 | Article |
| 英文摘要 | Investigations on the twigs and leaves of Antirhea chinensis have led to the discovery of two undescribed pentacyclic triterpenoids (1 and 2) and nine known analogs. Compounds 1 and 2, each assigned as the ursane and 24-noroleanane-type triterpenoids, featuring similar oxidation pattern of 3 beta,6 beta,19 alpha-trihydroxy-28-carboxyl. Their structures were elucidated via comprehensive analyses of spectroscopic data. Compound 1 displayed potent anti-HIV activity (EC50=1.24 mu M) and high selectivity index (SI >32.3). |
| WOS关键词 | SAPONINS ; INHIBITORS ; LIMONOIDS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000854112300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309302]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, AIDS Ctr, Montreal, PQ H3T 1E2, Canada; 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Jiao-Jiao,Han, Ying-Shan,Zhou, Bin,et al. Ursane and 24-Noroleanane-Type Triterpenoids with Anti-HIV Activity from the Twigs and Leaves of Antirhea chinensis[J]. CHEMISTRY & BIODIVERSITY,2022,19(10):e202200716. |
| APA | Cui, Jiao-Jiao,Han, Ying-Shan,Zhou, Bin,&Yue, Jian-Min.(2022).Ursane and 24-Noroleanane-Type Triterpenoids with Anti-HIV Activity from the Twigs and Leaves of Antirhea chinensis.CHEMISTRY & BIODIVERSITY,19(10),e202200716. |
| MLA | Cui, Jiao-Jiao,et al."Ursane and 24-Noroleanane-Type Triterpenoids with Anti-HIV Activity from the Twigs and Leaves of Antirhea chinensis".CHEMISTRY & BIODIVERSITY 19.10(2022):e202200716. |
入库方式： OAI收割
来源：上海药物研究所
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