Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
文献类型：期刊论文
| 作者 | Li, Chuan ; Jia, Wei-wei; Yang, Jun-ling; Cheng, Chen; Olaleye, Olajide E.
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2022-12 |
| 卷号 | 43期号:12页码:3080-3095 |
| 关键词 | Chinese herbal medicine pharmacokinetics multi-compound pharmacokinetic research drug-combination pharmacokinetic research pharmacokinetic compatibility |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00983-7 |
| 文献子类 | Review |
| 英文摘要 | Traditional medicine has provided a basis for health care and disease treatment to Chinese people for millennia, and herbal medicines are regulated as drug products in China. Chinese herbal medicines have two features. They normally possess very complex chemical composition. This makes the identification of the constituents that are together responsible for the therapeutic action of an herbal medicine challenging, because how to select compounds from an herbal medicine for pharmacodynamic study has been a big hurdle in such identification efforts. To this end, a multi-compound pharmacokinetic approach was established to identify potentially important compounds (bioavailable at the action loci with significant exposure levels after dosing an herbal medicine) and to characterize their pharmacokinetics and disposition. Another feature of Chinese herbal medicines is their typical use as or in combination therapies. Coadministration of complex natural products and conventional synthetic drugs is prevalent worldwide, even though it remains very controversial. Natural product-drug interactions have raised wide concerns about reduced drug efficacy or safety. However, growing evidence shows that incorporating Chinese herbal medicines into synthetic drug-based therapies delivers benefits in the treatment of many multifactorial diseases. To address this issue, a drug-combination pharmacokinetic approach was established to assess drug-drug interaction potential of herbal medicines and degree of pharmacokinetic compatibility for multi-herb combination and herbal medicine-synthetic drug combination therapies. In this review we describe the methodology, techniques, requirements, and applications of multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines and to discuss further development for these two types of pharmacokinetic research. |
| WOS关键词 | ST-JOHNS-WORT ; ANION-TRANSPORTING POLYPEPTIDES ; INTENSIVE-CARE-UNIT ; XUEBIJING INJECTION ; SYSTEMIC EXPOSURE ; HEPATIC-UPTAKE ; 3-MONOGLUCURONYL-GLYCYRRHETINIC ACID ; MOLECULAR-MECHANISMS ; PANAX-GINSENG ; EXTRACT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000854411500001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309303]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Chuan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chuan,Jia, Wei-wei,Yang, Jun-ling,et al. Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines[J]. ACTA PHARMACOLOGICA SINICA,2022,43(12):3080-3095. |
| APA | Li, Chuan,Jia, Wei-wei,Yang, Jun-ling,Cheng, Chen,&Olaleye, Olajide E..(2022).Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines.ACTA PHARMACOLOGICA SINICA,43(12),3080-3095. |
| MLA | Li, Chuan,et al."Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines".ACTA PHARMACOLOGICA SINICA 43.12(2022):3080-3095. |
入库方式： OAI收割
来源：上海药物研究所
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