Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective
文献类型：期刊论文
| 作者 | Liu, Jiao2,3; Gu, Yu-cheng4; Su, Ming-zhi1; Guo, Yue-wei1,2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2022-12 |
| 卷号 | 43期号:12页码:3062-3079 |
| 关键词 | marine natural products biological activity marine flora sponges soft corals mollusks |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00980-w |
| 文献子类 | Review |
| 英文摘要 | Marine organisms often produce a variety of metabolites with unique structures and diverse biological activities that enable them to survive and struggle in the extremely challenging environment. During the last two decades, our group devoted great effort to the discovery of pharmaceutically interesting lead compounds from South China Sea marine plants and invertebrates. We discovered numerous marine secondary metabolites spanning a wide range of structural classes, various biosynthetic origins and various aspects of biological activities. In a series of reviews, we have summarized the bioactive natural products isolated from Chinese marine flora and fauna found during 2000-2012. The present review provides an updated summary covering our latest research progress and development in the last decade (2012-2022) highlighting the discovery of over 400 novel marine secondary metabolites with promising bioactivities from South China Sea marine organisms. |
| WOS关键词 | SARCOPHYTON-TROCHELIOPHORUM MARENZELLER ; BROMINATED POLYUNSATURATED LIPIDS ; NUDIBRANCH JORUNNA-FUNEBRIS ; A-C ; ISOQUINOLINEQUINONE ALKALOIDS ; POLYHYDROXYLATED STEROIDS ; INHIBITORY-ACTIVITY ; NATURAL-PRODUCTS ; SPONGE ; DITERPENOIDS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000854658900001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309305]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Su, Ming-zhi; Guo, Yue-wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England; |
| 推荐引用方式 GB/T 7714 | Liu, Jiao,Gu, Yu-cheng,Su, Ming-zhi,et al. Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective[J]. ACTA PHARMACOLOGICA SINICA,2022,43(12):3062-3079. |
| APA | Liu, Jiao,Gu, Yu-cheng,Su, Ming-zhi,&Guo, Yue-wei.(2022).Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective.ACTA PHARMACOLOGICA SINICA,43(12),3062-3079. |
| MLA | Liu, Jiao,et al."Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective".ACTA PHARMACOLOGICA SINICA 43.12(2022):3062-3079. |
入库方式： OAI收割
来源：上海药物研究所
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