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Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer

文献类型：期刊论文

作者Chen, Xiaoxiao1; Feng, Jiamei1; Chen, Weili2; Shao, Shijun1; Chen, Li3,4; Wan, Hua1
刊名CELL COMMUNICATION AND SIGNALING
出版日期2022-09-12
卷号20期号:1页码:141
关键词Breast cancer sEVs Pre-metastatic niche Metastasis MiRNA Immunotherapy
DOI10.1186/s12964-022-00945-w
文献子类Review
英文摘要Breast cancer is the most common cancer in females, and to date, the mortality rate of breast cancer metastasis cannot be ignored. The metastasis of breast cancer is a complex, staged process, and the pattern of metastatic spread is not random. The pre-metastatic niche, as an organ-specific home for metastasis, is a favourable environment for tumour cell colonization. As detection techniques improve, the role of the pre-metastatic niche in breast cancer metastasis is being uncovered. sEVs (small extracellular vesicles) can deliver cargo, which is vital for the formation of pre-metastatic niches. sEVs participate in multiple aspects of creating a distant microenvironment to promote tumour invasion, including the secretion of inflammatory molecules, immunosuppression, angiogenesis and enhancement of vascular permeability, as well as regulation of the stromal environment. Here, we discuss the multifaceted mechanisms through which breast cancer-derived sEVs contribute to pre-metastatic niches. In addition, sEVs as biomarkers and antimetastatic therapies are also discussed, particularly their use in transporting exosomal microRNAs. The study of sEVs may provide insight into immunotherapy and targeted therapies for breast cancer, and we also provide an overview of their potential role in antitumour metastasis.
WOS关键词TUMOR-DERIVED EXOSOMES ; NONCODING RNA ; IN-VITRO ; MICRORNAS ; CELLS ; MEDIATORS ; BIOLOGY ; MARKERS ; ANGIOGENESIS ; PROGRESSION
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000853050900001
出版者BMC
源URL[http://119.78.100.183/handle/2S10ELR8/309306]  
专题新药研究国家重点实验室
通讯作者Wan, Hua
作者单位1.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Breast, Shanghai 200001, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Dept Breast, Yueyang Hosp Integated Tradit Chinese & Western M, Shanghai 200080, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xiaoxiao,Feng, Jiamei,Chen, Weili,et al. Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer[J]. CELL COMMUNICATION AND SIGNALING,2022,20(1):141.
APA Chen, Xiaoxiao,Feng, Jiamei,Chen, Weili,Shao, Shijun,Chen, Li,&Wan, Hua.(2022).Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer.CELL COMMUNICATION AND SIGNALING,20(1),141.
MLA Chen, Xiaoxiao,et al."Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer".CELL COMMUNICATION AND SIGNALING 20.1(2022):141.

入库方式： OAI收割

来源：上海药物研究所

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