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盘状结构域受体1 (DDR1)激酶抑制剂的研究进展

文献类型：期刊论文

作者葛天鹏1,2; 杨彦辰2,3; 李淳朴2; 张剑1; 柳红1,2
刊名有机化学
出版日期2022-09
卷号42期号:9页码:2760-2773
ISSN号0253-2786
关键词discoid domain receptor 1 (DDR1) inhibitor collagen
DOI10.6023/cjoc202204023
其他题名Research Progress of Discoid Domain Receptor 1 (DDR1) Inhibitors
文献子类Review
英文摘要Discoid domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase that plays a key role in regulating important processes, such as cell differentiation, proliferation, adhesion, migration, invasion and matrix remodeling. Overexpression or activation of DDR1 is closely related to the occurrence and development of inflammation, as well as tumor invasion and metastasis. Therefore, DDR1 is a potential target for the treatment of diseases, such as inflammation, fibrosis and malignancy. Since the early 1990s, a variety of DDR1 small molecule inhibitors have been reported successively. This article focuses on the structure, function, mechanism and signaling pathways of DDR1, and the design, structure-activity relationship and pharmacological activity of DDR1 small molecule inhibitors from the perspective of medicinal chemistry are reviewed.
WOS关键词BCR-ABL KINASE ; CELL-MIGRATION ; COLLAGEN I ; DISCOVERY ; CANCER ; IDENTIFICATION ; ACTIVATION ; EXPRESSION ; INVASION ; PATHWAY
WOS研究方向Chemistry
语种中文
出版者SCIENCE PRESS
WOS记录号WOS:000868890400009
源URL[http://119.78.100.183/handle/2S10ELR8/309307]  
专题新药研究国家重点实验室
通讯作者张剑; 柳红
作者单位1.Weifang Med Univ, Sch Pharm, Weifang 261053, Peoples R China;
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Ied, Shanghai 201203, Peoples R China;
3.China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China
推荐引用方式
GB/T 7714		 葛天鹏,杨彦辰,李淳朴,等. 盘状结构域受体1 (DDR1)激酶抑制剂的研究进展[J]. 有机化学,2022,42(9):2760-2773.
APA 葛天鹏,杨彦辰,李淳朴,张剑,&柳红.(2022).盘状结构域受体1 (DDR1)激酶抑制剂的研究进展.有机化学,42(9),2760-2773.
MLA 葛天鹏,et al."盘状结构域受体1 (DDR1)激酶抑制剂的研究进展".有机化学 42.9(2022):2760-2773.

入库方式： OAI收割

来源：上海药物研究所

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