Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
文献类型：期刊论文
| 作者 | Lin, Caiji1,2,3; Zeng, Zheng1,2,3; Lin, Yiru1,2,3; Wang, Pengfei1,2,3,7; Cao, Danli1,2,3; Xie, Kaihong1,2,3; Luo, Yao1,2,3; Yang, Hao6; Yang, Jiaming1,2,3; Wang, Wenxue1,2,3 |
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2022-11 |
| 卷号 | 106页码:154401 |
| 关键词 | Naringenin Ovarian cancer Gut microbiota PI3K |
| ISSN号 | 0944-7113 |
| DOI | 10.1016/j.phymed.2022.154401 |
| 文献子类 | Article |
| 英文摘要 | Background: Ovarian cancer has the highest mortality among all gynecological malignancies; currently, no effective therapeutics are available for its treatment. Naringenin has been shown to inhibit the progression of various cancers, but its inhibitory effect on ovarian cancer remains unknown. Purpose: This study aimed to evaluate the inhibitory effects of naringenin on ovarian cancer and elucidate the underlying mechanisms. Methods: Cancer cell proliferation was detected by cell counting kit-8 and crystal violet assays, and the migration capability was determined by wound healing and transwell assays. Western blotting and immunohistochemistry assays were employed to determine the expression levels of the epidermal growth factor receptor, phosphatidylinositol 3-kinase (PI3K) and cyclin D1 in vitro and in vivo, respectively. An ES-2 xenograft nude mouse model was established for the in vivo experiments, and fecal samples were collected for intestinal microbiota analysis by 16S rDNA sequencing. Results: Naringenin suppressed the proliferation and migration of A2780 and ES-2 cancer cell lines and down-regulated PI3K in vitro. In animal experiments, naringenin treatment significantly decreased the tumor weight and volume, and oral administration exhibited greater effects than intraperitoneal injection. Additionally, naringenin treatment ameliorated the population composition of the micmbiota in animals with ovarian cancer and significantly increased the abundances of Alistipes and Lactobacillus. Conclusion: Naringenin suppresses epithelial ovarian cancer by inhibiting PI3K pathway expression and ameliorating the gut microbiota, and the oral route is more effective than parenteral administration. |
| WOS关键词 | BREAST-CANCER ; METASTASIS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000848816200002 |
| 出版者 | ELSEVIER GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309309]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Huidi; Liu, Shu-Lin |
| 作者单位 | 1.Harbin Med Univ, Coll Pharm, Genom Res Ctr, State Prov Key Lab Biomed Pharmaceut China, Harbin 150081, Peoples R China; 2.Harbin Med Univ, Cumming Sch Med, Ctr Infect & Genom, Harbin 150081, Peoples R China; 3.Heilongjiang Acad Med Sci, Translat Med Res & Cooperat Ctr Northern China, Harbin 150081, Peoples R China; 4.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada; 5.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB T2N 4N1, Canada; 6.Harbin Chest Hosp, Dept Pathol, Harbin 150056, Peoples R China; 7.Shanghai Inst Mat Med, Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Caiji,Zeng, Zheng,Lin, Yiru,et al. Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota[J]. PHYTOMEDICINE,2022,106:154401. |
| APA | Lin, Caiji.,Zeng, Zheng.,Lin, Yiru.,Wang, Pengfei.,Cao, Danli.,...&Liu, Shu-Lin.(2022).Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota.PHYTOMEDICINE,106,154401. |
| MLA | Lin, Caiji,et al."Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota".PHYTOMEDICINE 106(2022):154401. |
入库方式： OAI收割
来源：上海药物研究所
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