A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of Aβ42
文献类型：期刊论文
| 作者 | Li, Saijuan1,2,3; Jin, Can1,2,3; Gao, Pengcheng1,2,3; Zhou, Wanqi1,3; Xiao, Rongrong1,2; Zhang, Zhenqiang4; Liao, Wenfeng1,2; Ding, Kan1,2,3,5,6
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2022-08-17 |
| 卷号 | 70期号:32页码:9908-9918 |
| 关键词 | Fructus Mori glycopeptide pectin A beta(42) aggregation APP processing Alzheimer's disease |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.2c03823 |
| 文献子类 | Article |
| 英文摘要 | The fruit of Fructus Mori is food and medicine, which has been demonstrated to have a significant neuroprotective effect. However, the effective constituent remains unknown. We speculate that the glycopeptide in the extract of the fruit has similar activity. To address this hypothesis, we isolated a novel pectin-like glycopeptide (FMP-6-S4) with a molecular weight of 11.23 kDa from the fruit. It contains about 20% of peptide comprising 17 amino acids and 80% glycan consisting of L-rhamnose (L-Rha), D-galactose (D-Gal), D-galacturonic acid (D-GalA), L-arabinose (L-Ara) and d-glucose (D-Glc) in molar ratios of 7.25:4.62:77.66:5.62:4.85. The backbone of the glycan part consisted of 1,4-linked alpha-D-GalpA and 1, 2-linked alpha-L-Rhap, while the branches were composed of hexenuronic acid (HexA) substituted at the C-3 position of partial galacturonic acid, and traces of galactose, glucose, and arabinose were substituted at the C-4 position of rhamnose. The in vitro experiments revealed that FMP-6-S4 might inhibit A beta(42) (beta-amyloid peptides 42) aggregation and decrease A beta(42) production by modulating APP (amyloid precursor protein) processing. |
| WOS关键词 | PROTEIN-BOUND POLYSACCHARIDE ; STRUCTURAL-CHARACTERIZATION ; ANTITUMOR-ACTIVITY ; HEXENURONIC ACID ; L. ; PROTEOGLYCANS ; PATHOGENESIS ; BIOACTIVITY ; HEPARIN ; MODEL |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000837963100001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309314]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liao, Wenfeng; Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res,Glycochem &Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; 4.Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou 450046, Peoples R China; 5.Henan Univ Chinese Med, Henan Polysaccharide Res Ctr, Zhengzhou 450046, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Saijuan,Jin, Can,Gao, Pengcheng,et al. A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of Aβ42[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(32):9908-9918. |
| APA | Li, Saijuan.,Jin, Can.,Gao, Pengcheng.,Zhou, Wanqi.,Xiao, Rongrong.,...&Ding, Kan.(2022).A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of Aβ42.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(32),9908-9918. |
| MLA | Li, Saijuan,et al."A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of Aβ42".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.32(2022):9908-9918. |
入库方式： OAI收割
来源：上海药物研究所
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