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Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer

文献类型：期刊论文

作者Zhao, Zitong1,2,3,4; Fang, Lei1,2; Xiao, Ping1,2; Sun, Xiangshi1,2; Zhou, Lei1,2; Liu, Xiaochen1,2; Wang, Jue1,2; Wang, Guanru1,2; Cao, Haiqiang1,2; Zhang, Pengcheng1,2,3
刊名ADVANCED MATERIALS
出版日期2022-08
卷号34期号:33页码:2205462
ISSN号0935-9648
关键词chemo-immunotherapy drug delivery metastasis PD-1 blockade triple-negative breast cancer
DOI10.1002/adma.202205462
文献子类Article
英文摘要Lung metastasis is challenging in patients with triple-negative breast cancer (TNBC). Surgery is always not available due to the dissemination of metastatic foci and most drugs are powerless because of poor retention at metastatic sites. TNBC cells generate an inflamed microenvironment and overexpress adhesive molecules to promote invasion and colonization. Herein, walking dead TNBC cells are developed through conjugating anti-PD-1 (programmed death protein 1 inhibitor) and doxorubicin (DOX)-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells maintain plenary tumor antigens to conduct vaccination effects. Anti-PD-1 antibodies are conjugated to cell corpses via reduction-activated linker, and DOX-loaded liposomes are attached by maleimide-thiol coupling. This anchor strategy enables rapid release of anti-PD-1 upon reduction conditions while long-lasting release of DOX at inflamed metastatic sites. The walking dead TNBC cells improve pulmonary accumulation and local retention of drugs, reprogram the lung microenvironment through damage-associated molecular patterns (DAMPs) and PD-1 blockade, and prolong overall survival of lung metastatic 4T1 and EMT6-bearing mice. Taking advantage of the walking dead TNBC cells for pulmonary preferred delivery of chemotherapeutics and checkpoint inhibitors, this study suggests an alternative treatment option of chemo-immunotherapy to augment the efficacy against lung metastasis.
WOS关键词NANOPARTICLES ; EFFICACY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000825661400001
源URL[http://119.78.100.183/handle/2S10ELR8/309318]  
专题新药研究国家重点实验室
通讯作者Jiang, Yanyan; Wang, Dangge; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China;
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China;
5.Bohai Rim Adv Res Inst Drug Discovery, Shangdong Lab Yantai Drug Discovery, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Zitong,Fang, Lei,Xiao, Ping,et al. Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer[J]. ADVANCED MATERIALS,2022,34(33):2205462.
APA Zhao, Zitong.,Fang, Lei.,Xiao, Ping.,Sun, Xiangshi.,Zhou, Lei.,...&Li, Yaping.(2022).Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer.ADVANCED MATERIALS,34(33),2205462.
MLA Zhao, Zitong,et al."Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer".ADVANCED MATERIALS 34.33(2022):2205462.

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来源：上海药物研究所

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