Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib
文献类型：期刊论文
| 作者 | Wang, Guanru1,2; Xie, Yaru1,2,3; Qian, Xindi1,2; Zhang, Xinyue1,2; Shan, Yanqiang4; Zhang, Minghui5; Li, Jie1,2; Zhang, Zhiwen1,2 ; Li, Yaping1,2,3,6
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| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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| 出版日期 | 2022-03-04 |
| 卷号 | 48期号:3页码:109-116 |
| 关键词 | Gefitinib nanovehicle oral bioavailability poorly water soluble drugs bioadhesive |
| ISSN号 | 0363-9045 |
| DOI | 10.1080/03639045.2022.2098316 |
| 文献子类 | Article |
| 英文摘要 | The poor water solubility and inadequate oral bioavailability of gefitinib (Gef) remain a critical issue to achieve the therapeutic outcomes. Herein, we designed a poly(maleic anhydride-alt-1-octadecene) (PMA/C18) based lipid nanovehicle (PLN) to improve the intestinal absorption and oral bioavailability of poorly water-soluble Gef. PLN was nanometer-sized particles, and Gef was dispersed in the PLN formulation as amorphous or molecular state. At 4 h of oral administration, the tissue concentration of Gef in duodenum, jejunum, and ileum was profoundly enhanced 3.37-, 8.94-, and 8.09-fold by PLN when comparing to the counterpart lipid nanovehicle. Moreover, the oral bioavailability of Gef was significantly enhanced 2.48-fold by the PLN formulation when comparing to the free drug suspension. Therefore, this study provides an encouraging bioadhesive delivery platform to improve the oral delivery of poorly water-soluble drugs. |
| WOS关键词 | SOLID LIPID NANOPARTICLES ; IN-VITRO ; DELIVERY ; PHARMACOKINETICS ; ABSORPTION ; FORMULATION ; SOLUBILITY ; PACLITAXEL ; CANCER ; DRUGS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000825446700001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309320]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai, Peoples R China; 3.Yantai Univ, Sch Pharm, Yantai, Peoples R China; 4.Qilu Pharmaceut Hainan Co Ltd, Haikou, Hainan, Peoples R China; 5.Qilu Pharmaceut Co Ltd, Jinan, Peoples R China; 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Guanru,Xie, Yaru,Qian, Xindi,et al. Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2022,48(3):109-116. |
| APA | Wang, Guanru.,Xie, Yaru.,Qian, Xindi.,Zhang, Xinyue.,Shan, Yanqiang.,...&Li, Yaping.(2022).Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,48(3),109-116. |
| MLA | Wang, Guanru,et al."Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 48.3(2022):109-116. |
入库方式： OAI收割
来源：上海药物研究所
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