Organic single molecule based nano-platform for NIR-II imaging and chemo-photothermal synergistic treatment of tumor
文献类型：期刊论文
| 作者 | Chang, Tonghang1,2; Qiu, Qing2,4; Ji, Aiyan2; Qu, Chunrong1,2,5; Chen, Hao1,2,3; Cheng, Zhen1,2,3,5 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2022-08 |
| 卷号 | 287页码:121670 |
| 关键词 | Chemo-photothermalcombinationtreatment NIR-IIimaging Singlemoleculephototheranostics Organicdye |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2022.121670 |
| 文献子类 | Article |
| 英文摘要 | Integrating multiple functionalities of near-infrared second window fluorescence imaging (NIR-II FLI), chemo-therapy, and photothermal treatment (PTT) into a single molecule is desirable but still a highly challenging task. Herein, inspired by the results that hyperthermia can enhance the cytotoxicity of some alkylating agents, we designed and synthesized the novel compound NM. By introducing nitrogen mustard's active moiety bis(2-chlorethyl)amino into Donor-Acceptor-Donor (D-A-D) electronic structure, the unimolecular system not only behaviored as a chemotherapeutic agent but also exhibited good PTT and NIR-II FLI abilities. The hydrophobic agent NM was encapsulated by DSPE-PEG2000 to generate the nano-platform NM-NPs. The current study on in vitro and in vivo experiments indicated that NM-NPs make vessels visualize clearly in the NIR-II zone and achieve complete tumor elimination through chemo-photothermal synergistic treatment. Overall, this study provides a new innovative strategy for developing superior, versatile phototheranostics for cancer theranostics. |
| WOS关键词 | NITROGEN-MUSTARD ; CANCER-THERAPY ; QUANTUM DOTS ; DYE ; WINDOW ; BRAIN |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000829226200001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309321]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qu, Chunrong; Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China; 4.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Tonghang,Qiu, Qing,Ji, Aiyan,et al. Organic single molecule based nano-platform for NIR-II imaging and chemo-photothermal synergistic treatment of tumor[J]. BIOMATERIALS,2022,287:121670. |
| APA | Chang, Tonghang,Qiu, Qing,Ji, Aiyan,Qu, Chunrong,Chen, Hao,&Cheng, Zhen.(2022).Organic single molecule based nano-platform for NIR-II imaging and chemo-photothermal synergistic treatment of tumor.BIOMATERIALS,287,121670. |
| MLA | Chang, Tonghang,et al."Organic single molecule based nano-platform for NIR-II imaging and chemo-photothermal synergistic treatment of tumor".BIOMATERIALS 287(2022):121670. |
入库方式： OAI收割
来源：上海药物研究所
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