中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Current approaches of nanomedicines in the market and various stage of clinical translation

文献类型:期刊论文

作者Shan, Xiaoting1,2,4; Gong, Xiang1,2; Li, Jie1,2,3; Wen, Jingyuan5; Li, Yaping1,2,4; Zhang, Zhiwen1,2,3,4
刊名ACTA PHARMACEUTICA SINICA B
出版日期2022-07
卷号12期号:7页码:3028-3048
关键词Nanomedicines Nanoparticles Liposomes Vaccines Marketed products Clinical translations Disease-driven design Quality by design
ISSN号2211-3835
DOI10.1016/j.apsb.2022.02.025
文献子类Review
英文摘要Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of nanomedicines that have been currently launched or in the clinical trials, which manifests a diversified trend in carrier types, applied indications and mechanisms of action. From the perspective of indications, this article presents an overview of the applications of nanomedicines involving the preven-tion, diagnosis and treatment of various diseases, which include cancer, infections, blood disorders, car-diovascular diseases, immuno-associated diseases and nervous system diseases, etc. Moreover, the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词CONVECTION-ENHANCED DELIVERY ; ASPARTATE-BETA-HYDROXYLASE ; POLYMER-BASED NANOPARTICLE ; ADVANCED PANCREATIC-CANCER ; MONOPHOSPHORYL-LIPID-A ; LAHERPAREPVEC T-VEC ; DRUG-DELIVERY ; GENE-THERAPY ; TARGETED DELIVERY ; VACCINE
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000827613600004
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/309323]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China;
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China;
5.Univ Auckland, Sch Pharm, Auckland 1142, New Zealand
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GB/T 7714
Shan, Xiaoting,Gong, Xiang,Li, Jie,et al. Current approaches of nanomedicines in the market and various stage of clinical translation[J]. ACTA PHARMACEUTICA SINICA B,2022,12(7):3028-3048.
APA Shan, Xiaoting,Gong, Xiang,Li, Jie,Wen, Jingyuan,Li, Yaping,&Zhang, Zhiwen.(2022).Current approaches of nanomedicines in the market and various stage of clinical translation.ACTA PHARMACEUTICA SINICA B,12(7),3028-3048.
MLA Shan, Xiaoting,et al."Current approaches of nanomedicines in the market and various stage of clinical translation".ACTA PHARMACEUTICA SINICA B 12.7(2022):3028-3048.

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来源:上海药物研究所

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