Current approaches of nanomedicines in the market and various stage of clinical translation
文献类型：期刊论文
| 作者 | Shan, Xiaoting1,2,4; Gong, Xiang1,2; Li, Jie1,2,3; Wen, Jingyuan5; Li, Yaping1,2,4 ; Zhang, Zhiwen1,2,3,4
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| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2022-07 |
| 卷号 | 12期号:7页码:3028-3048 |
| 关键词 | Nanomedicines Nanoparticles Liposomes Vaccines Marketed products Clinical translations Disease-driven design Quality by design |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2022.02.025 |
| 文献子类 | Review |
| 英文摘要 | Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of nanomedicines that have been currently launched or in the clinical trials, which manifests a diversified trend in carrier types, applied indications and mechanisms of action. From the perspective of indications, this article presents an overview of the applications of nanomedicines involving the preven-tion, diagnosis and treatment of various diseases, which include cancer, infections, blood disorders, car-diovascular diseases, immuno-associated diseases and nervous system diseases, etc. Moreover, the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS关键词 | CONVECTION-ENHANCED DELIVERY ; ASPARTATE-BETA-HYDROXYLASE ; POLYMER-BASED NANOPARTICLE ; ADVANCED PANCREATIC-CANCER ; MONOPHOSPHORYL-LIPID-A ; LAHERPAREPVEC T-VEC ; DRUG-DELIVERY ; GENE-THERAPY ; TARGETED DELIVERY ; VACCINE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000827613600004 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309323]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China; 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China; 5.Univ Auckland, Sch Pharm, Auckland 1142, New Zealand |
| 推荐引用方式 GB/T 7714 | Shan, Xiaoting,Gong, Xiang,Li, Jie,et al. Current approaches of nanomedicines in the market and various stage of clinical translation[J]. ACTA PHARMACEUTICA SINICA B,2022,12(7):3028-3048. |
| APA | Shan, Xiaoting,Gong, Xiang,Li, Jie,Wen, Jingyuan,Li, Yaping,&Zhang, Zhiwen.(2022).Current approaches of nanomedicines in the market and various stage of clinical translation.ACTA PHARMACEUTICA SINICA B,12(7),3028-3048. |
| MLA | Shan, Xiaoting,et al."Current approaches of nanomedicines in the market and various stage of clinical translation".ACTA PHARMACEUTICA SINICA B 12.7(2022):3028-3048. |
入库方式： OAI收割
来源：上海药物研究所
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