A novel NIR-II nanoprobe for precision imaging of micro-meter sized tumor metastases of multi-organs and skin flap
文献类型：期刊论文
| 作者 | Lou, Hongyue1,2; Ji, Aiyan2; Qu, Chunrong2; Duan, Shuang1,2; Liu, Hongguang1; Chen, Hao2,4; Cheng, Zhen2,3,4 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 449页码:137848 |
| 关键词 | NIR-II imaging Tumor metastases D-A-D dye Skip flap |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2022.137848 |
| 文献子类 | Article |
| 英文摘要 | Near-infrared window II (NIR-II, 1000 - 1700 nm) imaging shows high promise for medical applications. Novel NIR-II dyes are the driving force to realize and broaden the biomedical applications of this newly rising imaging technique. Herein, we designed a novel small molecular NIR-II dye IT-TQT using a new strategy and further loaded the dye into DSPE-PEG2000 to obtain IT-TQT nanoparticles (NPs) for bioimaging. Specifically, IT-TQT was integrated a novel component 6,7-di(thiophen-2-yl)- [1,2,5] thiadiazolo[3,4-g] quinoxaline (TQT) as electron acceptor and the indole group widely presented in pharmaceuticals as a novel electron donor. Taking advantage of the excellent photophysical properties of IT-TQT nanoprobe (diameter: 11.2 nm; maximum emission: 1015 nm), IT-TQT NPs clearly delineated tumors in subcutaneous mice models and realized the detection of even micro-meter (down to 90 mu m) ultrasmall tumors presented in multiple organs in living tumor metastases mice models. Furthermore, the vasculatures as small as 63.5 mu m in diameter were also identified in mice blood vessel imaging using IT-TQT NPs. Lastly, the survival area of the small animal mice and large animal porcine skin flap were successfully visualized by IT-TQT NPs. Overall, IT-TQT nanoprobe has high potential for broad biomedical applications and clinical translation. |
| WOS关键词 | INDOCYANINE GREEN ICG ; FLUORESCENCE ; FLUOROPHORES |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000824764800003 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309329]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Northeastern Univ, Inst Mol Med Joint Lab Mol Med, Shenyang 110000, Liaoning, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lou, Hongyue,Ji, Aiyan,Qu, Chunrong,et al. A novel NIR-II nanoprobe for precision imaging of micro-meter sized tumor metastases of multi-organs and skin flap[J]. CHEMICAL ENGINEERING JOURNAL,2022,449:137848. |
| APA | Lou, Hongyue.,Ji, Aiyan.,Qu, Chunrong.,Duan, Shuang.,Liu, Hongguang.,...&Cheng, Zhen.(2022).A novel NIR-II nanoprobe for precision imaging of micro-meter sized tumor metastases of multi-organs and skin flap.CHEMICAL ENGINEERING JOURNAL,449,137848. |
| MLA | Lou, Hongyue,et al."A novel NIR-II nanoprobe for precision imaging of micro-meter sized tumor metastases of multi-organs and skin flap".CHEMICAL ENGINEERING JOURNAL 449(2022):137848. |
入库方式： OAI收割
来源：上海药物研究所
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