Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata
文献类型：期刊论文
| 作者 | Chen, Bao1,2; Qiu, Peiju2; Xu, Baofu1; Zhao, Qingmin3,4; Gu, Yu-Cheng5; Fu, Lei2; Bi, Shijie2; Lan, Lefu3,4 ; Wang, Chang-Yun2; Guo, Yue-Wei1,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2022-07-22 |
| 卷号 | 85期号:7页码:1799-1807 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.2c00348 |
| 文献子类 | Article |
| 英文摘要 | Nine new isomalabaricane terpenoids (1-9) were isolated from the sponge Rhabdastrella globostellata of Ximao Island, together with 13 known ones (10-22). The structures were established by spectroscopic data interpretation and chemical calculations, as well as by comparison with spectroscopic data of known compounds. Notably, of the new isolates, hainanstelletin A (5) is the first representative of a nitrogenous isomalabaricane. The isolated compounds were evaluated against several cancer cell lines and two bacterial pathogens. In addition, moderate to strong antibacterial activities against Streptococcus pyogenes were also detected among geometric isomers 1, 2, and 10-12, with minimum inhibitory concentrations of 0.1-1.8 mu g/mL. |
| WOS关键词 | MARINE SPONGE ; NATURAL-PRODUCTS ; TRITERPENES ; NORTRITERPENOIDS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000823238000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309334]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lan, Lefu; Wang, Chang-Yun; Guo, Yue-Wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China; 2.Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England |
| 推荐引用方式 GB/T 7714 | Chen, Bao,Qiu, Peiju,Xu, Baofu,et al. Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(7):1799-1807. |
| APA | Chen, Bao.,Qiu, Peiju.,Xu, Baofu.,Zhao, Qingmin.,Gu, Yu-Cheng.,...&Guo, Yue-Wei.(2022).Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata.JOURNAL OF NATURAL PRODUCTS,85(7),1799-1807. |
| MLA | Chen, Bao,et al."Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata".JOURNAL OF NATURAL PRODUCTS 85.7(2022):1799-1807. |
入库方式： OAI收割
来源：上海药物研究所
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