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1064 nm activatable semiconducting polymer-based nanoplatform for NIR-II fluorescence/NIR-II photoacoustic imaging guided photothermal therapy of orthotopic osteosarcoma

文献类型：期刊论文

作者Li, Daifeng1; Zhang, Chi1; Tai, Xiaoyan2,5; Xu, Denghui1; Xu, Jianzhong1; Sun, Pengfei2,5; Fan, Quli2,5; Cheng, Zhen3,4; Zhang, Yi1
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2022-10-01
卷号445页码:136836
关键词Semiconducting Polymer NIR-II Fluorescence Imaging NIR-II Photoacoustic Imaging NIR-II Photothermal Therapy Orthotopic Osteosarcoma
ISSN号1385-8947
DOI10.1016/j.cej.2022.136836
文献子类Article
英文摘要As a promising anti-tumoral approach, photothermal therapy (PTT) with NIR-II (1000-1700 nm) absorption could penetrate deeper and generate more efficient hyperthermia in contrast to traditional PTT under 808 nm irradiation. As for optical tracking, NIR-II fluorescence imaging (FI) and NIR-II photoacoustic imaging (PAI) are the two emerging research hotspots. Unfortunately, each single modality has its intrinsic limitations and current research to integrate them in one-component system is still in infancy. Our development of all-in-one nanoplatforms aims to ultimately improve the efficacy of targeted hyperthermia, and incorporate the benefits of NIRII FI and NIR-II PAI for tracking guidance. Herein, we designed a novel semiconducting polymer P2, and further encapsulated it with amphiphilic PEGylated phospholipid modified with a targeting peptide RGD to ultimately generate P2 based nanoparticles (P2NPs). As a single-component phototheranostic nanoplatform, P2NPs possessed intense NIR-II absorption, excellent NIR-II fluorescence, strong NIR-II PA signals, and high local hyperthermia capability simultaneously. Notably, due to the favorable binding capacity to osteosarcoma (OS) cells, in vitro studies revealed outstanding PTT efficacy of P2NPs against 143B cells under 1064 nm laser. Further work validated excellent dual-modal NIR-II FI/NIR-II PAI tracking and strong PTT tumor ablation in both subcutaneous and orthotopic OS mice models with negligible biotoxicity in vivo. Consequently, these findings warranted P2NPs as a promising 1064 nm activatable all-in-one nanoplatform to perform dual-modal NIR-II FI/NIRII PAI-guided orthotopic tumoral treatment, providing a new approach for theranostics, therapeutic tracking, and the beyond in other diseases.
WOS关键词NANOPARTICLES
WOS研究方向Engineering
语种英语
WOS记录号WOS:000800863200001
出版者ELSEVIER SCIENCE SA
源URL[http://119.78.100.183/handle/2S10ELR8/309347]  
专题新药研究国家重点实验室
通讯作者Sun, Pengfei; Cheng, Zhen; Zhang, Yi
作者单位1.Zhengzhou Univ, Affiliated Hosp 1, Dept Orthopaed, Zhengzhou 450052, Peoples R China;
2.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med Chinese Acad Sci, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Peoples R China;
5.Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Li, Daifeng,Zhang, Chi,Tai, Xiaoyan,et al. 1064 nm activatable semiconducting polymer-based nanoplatform for NIR-II fluorescence/NIR-II photoacoustic imaging guided photothermal therapy of orthotopic osteosarcoma[J]. CHEMICAL ENGINEERING JOURNAL,2022,445:136836.
APA Li, Daifeng.,Zhang, Chi.,Tai, Xiaoyan.,Xu, Denghui.,Xu, Jianzhong.,...&Zhang, Yi.(2022).1064 nm activatable semiconducting polymer-based nanoplatform for NIR-II fluorescence/NIR-II photoacoustic imaging guided photothermal therapy of orthotopic osteosarcoma.CHEMICAL ENGINEERING JOURNAL,445,136836.
MLA Li, Daifeng,et al."1064 nm activatable semiconducting polymer-based nanoplatform for NIR-II fluorescence/NIR-II photoacoustic imaging guided photothermal therapy of orthotopic osteosarcoma".CHEMICAL ENGINEERING JOURNAL 445(2022):136836.

入库方式： OAI收割

来源：上海药物研究所

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