Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry
文献类型：期刊论文
| 作者 | Lin, Na1,2; Zhang, Meng-Meng2; Jiang, Cheng-Shi4; Li, Jia2 ; Wang, Hong1; Shen, Yi-Ran2; Guo, Yue-Wei1,2,3
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2022-04-13 |
| 卷号 | 95页码:153719 |
| 关键词 | Soft coral Cladiella krempfi Eunicellin 9, 11-secosteroid X-ray diffraction |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2022.153719 |
| 文献子类 | Article |
| 英文摘要 | Two new compounds, namely an uncommon eunicellin-based diterpenoid (clakrefielin A, 2) and a 9, 11secosteroid (cladiellasterol A, 4), along with a known carotenoid (all-trans-peridinin, 7), were isolated from the Ximao Island, Sanya Bay soft coral Cladiella krempfi. The structures of these compounds were established on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, chemical transformations, as well as the comparison with the reported data in the literature. The biological activities of these compounds were investigated, and compound 7 was found to be a new protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 7.2 lM). (c) 2022 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000792912100012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309353]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Peoples R China; 4.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Na,Zhang, Meng-Meng,Jiang, Cheng-Shi,et al. Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry[J]. TETRAHEDRON LETTERS,2022,95:153719. |
| APA | Lin, Na.,Zhang, Meng-Meng.,Jiang, Cheng-Shi.,Li, Jia.,Wang, Hong.,...&Guo, Yue-Wei.(2022).Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry.TETRAHEDRON LETTERS,95,153719. |
| MLA | Lin, Na,et al."Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry".TETRAHEDRON LETTERS 95(2022):153719. |
入库方式： OAI收割
来源：上海药物研究所
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