Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl
文献类型：期刊论文
| 作者 | Xu, Ya-Ming1; Wijeratne, E. M. Kithsiri1; Liu, Manping X.1; Xuan, Lijiang2 ; Wang, Wenqiong2; Gunatilaka, A. A. Leslie1
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| 刊名 | MOLECULES
 |
| 出版日期 | 2022-02 |
| 卷号 | 27期号:3页码:909 |
| 关键词 | plants of Solanaceae aeroponic cultivation Physalis coztomatl withanolides anticancer activity prostate cancer |
| DOI | 10.3390/molecules27030909 |
| 文献子类 | Article |
| 英文摘要 | Withanolides constitute one of the most interesting classes of natural products due to their diversity of structures and biological activities. Our recent studies on withanolides obtained from plants of Solanaceae including Withania somnifera and a number of Physalis species grown under environmentally controlled aeroponic conditions suggested that this technique is a convenient, reproducible, and superior method for their production and structural diversification. Investigation of aeroponically grown Physalis coztomatl afforded 29 withanolides compared to a total of 13 obtained previously from the wild-crafted plant and included 12 new withanolides, physacoztolides I-M (9-13), 15 alpha-acetoxy-28-hydroxyphysachenolide C (14), 28-oxophysachenolide C (15), and 28-hydroxyphysachenolide C (16), 5 alpha-chloro-6 beta-hydroxy-5,6-dihydrophysachenolide D (17), 15 alpha-acetoxy-5 alpha-chloro-6 beta-hydroxy-5,6-dihydrophysachenolide D (18), 28-hydroxy-5 alpha-chloro-6 beta-hydroxy-5,6-dihydrophysachenolide D (19), physachenolide A-5-methyl ether (20), and 17 known withanolides 3-5, 8, and 21-33. The structures of 9-20 were elucidated by the analysis of their spectroscopic data and the known withanolides 3-5, 8, and 21-33 were identified by comparison of their spectroscopic data with those reported. Evaluation against a panel of prostate cancer (LNCaP, VCaP, DU-145, and PC-3) and renal carcinoma (ACHN) cell lines, and normal human foreskin fibroblast (WI-38) cells revealed that 8, 13, 15, and 17-19 had potent and selective activity for prostate cancer cell lines. Facile conversion of the 5,6-chlorohydrin 17 to its 5,6-epoxide 8 in cell culture medium used for the bioassay suggested that the cytotoxic activities observed for 17-19 may be due to in situ formation of their corresponding 5 beta,6 beta-epoxides, 8, 27, and 28. |
| WOS关键词 | WITHANIA-SOMNIFERA ; PROSTATE-CANCER ; CHLORINATED WITHANOLIDES ; SELECTIVE CYTOTOXICITY ; CONSTITUENTS ; LABDANES ; POTENT |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000755375100001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309360]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gunatilaka, A. A. Leslie |
| 作者单位 | 1.Univ Arizona, Southwest Ctr Nat Prod Res, Sch Nat Resources & Environm, Coll Agr & Life Sci, 250 E Valencia Rd, Tucson, AZ 85706 USA; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ya-Ming,Wijeratne, E. M. Kithsiri,Liu, Manping X.,et al. Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl[J]. MOLECULES,2022,27(3):909. |
| APA | Xu, Ya-Ming,Wijeratne, E. M. Kithsiri,Liu, Manping X.,Xuan, Lijiang,Wang, Wenqiong,&Gunatilaka, A. A. Leslie.(2022).Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl.MOLECULES,27(3),909. |
| MLA | Xu, Ya-Ming,et al."Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl".MOLECULES 27.3(2022):909. |
入库方式： OAI收割
来源：上海药物研究所
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