Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
文献类型：期刊论文
| 作者 | He, Wenxiu1; Zhang, Zhiwen2,3 ; Sha, Xianyi1,4
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2021-10 |
| 卷号 | 277页码:121111 |
| 关键词 | Ischemic stroke Nanoparticles Recanalization therapy Neuroprotection therapy Combination therapy |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2021.121111 |
| 文献子类 | Article |
| 英文摘要 | Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic stroke, this review outline and summarize the rationally designed nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. On this bases, the potentials and challenges of nanoparticles in the treatment of ischemic stroke are revealed, and new thoughts and perspectives are proposed for the design of feasible nanoparticles for effective treatment of ischemic stroke. |
| WOS关键词 | HEME OXYGENASE-1 GENE ; LIPOSOME-ENCAPSULATED HEMOGLOBIN ; BLOOD-BRAIN-BARRIER ; CHROMATIN PROTEIN HMGB1 ; NEURAL STEM-CELLS ; CEREBRAL-ISCHEMIA ; DRUG-DELIVERY ; TARGETED DELIVERY ; OXIDATIVE STRESS ; NITRIC-OXIDE |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000700601800003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309370]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Sha, Xianyi |
| 作者单位 | 1.Fudan Univ, Minist Educ, Sch Pharm, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Fudan Univ, Inst Integrat Med, 120 Urumqi Middle Rd, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Wenxiu,Zhang, Zhiwen,Sha, Xianyi. Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke[J]. BIOMATERIALS,2021,277:121111. |
| APA | He, Wenxiu,Zhang, Zhiwen,&Sha, Xianyi.(2021).Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke.BIOMATERIALS,277,121111. |
| MLA | He, Wenxiu,et al."Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke".BIOMATERIALS 277(2021):121111. |
入库方式： OAI收割
来源：上海药物研究所
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