Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles
文献类型：期刊论文
| 作者 | De Vrieze, Jana1; Baptista, Antonio P.2,3; Nuhn, Lutz4; Van Herck, Simon1; Deswarte, Kim2,3; Yu, Haijun5 ; Lambrecht, Bart N.2,3,6; De Geest, Bruno G.1
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| 刊名 | ADVANCED THERAPEUTICS
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| 出版日期 | 2021-08 |
| 卷号 | 4期号:8页码:2100079 |
| 关键词 | adjuvants amphiphiles immunity lipids lymph node |
| DOI | 10.1002/adtp.202100079 |
| 文献子类 | Article |
| 英文摘要 | Immunomodulatory drugs are of great relevance in the context of vaccine delivery and cancer immunotherapy. Due to the ubiquitous presence of immune cells throughout the body, gaining control over the biodistribution and activity of such drugs is crucial to limit off-target inflammatory responses. Here, the authors report on lipid-PEG (polyethylene glycol) amphiphiles as well-defined amphiphilic carries for lymph node targeted delivery. Comparing cholesterol and dialkyl lipids with different alkyl chain length, the authors found that both the nature of the lipid, as well as, the alkyl chain length have a dramatic influence on cellular uptake and lymph node translocation. Whereas shorter dioctyl-PEG amphiphiles show overall poor performance, larger dioctadecyl-PEG amphiphiles are prone to solubility issues. Didodecyl-PEG amphiphiles with intermediate alkyl chain length are on par with cholesteryl-PEG amphiphiles in in vitro and in vivo cellular uptake and lymphoid tissue targeting. Immunization with a cholesteryl-PEG-imidazoquinoline (TLR7/8 agonist) amphiphile-adjuvanted model antigen shows induction of immune responses that are qualitatively different from Montanide-adjuvanted antigen, characterized by effector CD8(+) T cells with immediate cytotoxic potential and robust IgG2 antibody responses. These findings provide a rational base for further adjuvant design based on the type of immunity needed for a specific vaccination or therapeutic setting. |
| WOS关键词 | IMMUNITY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000678888100001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309375]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | De Geest, Bruno G. |
| 作者单位 | 1.Univ Ghent, Dept Pharmaceut, Ottergemsesteenweg 460, B-9000 Ghent, Belgium; 2.Univ Ghent, VIB, Lab Immunoregulat & Mucosal Immunol, Ctr Inflammat Res, Technol Pk Zwijnaarde 71, B-9052 Ghent, Belgium; 3.Univ Ghent, Dept Internal Med & Pediat, C Heymansla 10, B-9000 Ghent, Belgium; 4.Max Planck Inst Polymer Res Ackermannweg, D-55128 Mainz, Germany; 5.Chinese Acad Sci, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 6.Erasmus Univ, Dept Pulm Med, Med Ctr, Dr Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands |
| 推荐引用方式 GB/T 7714 | De Vrieze, Jana,Baptista, Antonio P.,Nuhn, Lutz,et al. Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles[J]. ADVANCED THERAPEUTICS,2021,4(8):2100079. |
| APA | De Vrieze, Jana.,Baptista, Antonio P..,Nuhn, Lutz.,Van Herck, Simon.,Deswarte, Kim.,...&De Geest, Bruno G..(2021).Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles.ADVANCED THERAPEUTICS,4(8),2100079. |
| MLA | De Vrieze, Jana,et al."Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles".ADVANCED THERAPEUTICS 4.8(2021):2100079. |
入库方式： OAI收割
来源：上海药物研究所
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