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Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

文献类型：期刊论文

作者Song, Rundi1,2; Li, Tianliang1,2; Ye, Jiayi1,2; Sun, Fang1,2; Hou, Bo1,2,3; Saeed, Madiha1,2; Gao, Jing1,2; Wang, Yingjie1,2; Zhu, Qiwen1,2; Xu, Zhiai3
刊名ADVANCED MATERIALS
出版日期2021-06-25
卷号33期号:31页码:2101155
关键词cancer immunotherapy ferroptosis immune resistance immunogenic cell death T lymphocytes
ISSN号0935-9648
DOI10.1002/adma.202101155
文献子类Article
英文摘要Immunotherapy shows promising therapeutic potential for long-term tumor regression. However, current cancer immunotherapy displays a low response rate due to insufficient immunogenicity of the tumor cells. To address these challenges, herein, intracellular-acidity-activatable dynamic nanoparticles for eliciting immunogenicity by inducing ferroptosis of the tumor cells are engineered. The nanoparticles are engineered by integrating an ionizable block copolymer and acid-liable phenylboronate ester (PBE) dynamic covalent bonds for tumor-specific delivery of the ferroptosis inducer, a glutathione peroxidase 4 inhibitor RSL-3. The nanoparticles can stably encapsulate RSL-3 inside the hydrophobic core via pi-pi stacking interaction with the PBE groups at neutral pH (pH = 7.4), while releasing the payload in the endocytic vesicles (pH = 5.8-6.2) by acidity-triggered cleavage of the PBE dynamic covalent bonds. Furthermore, the nanoparticles can perform acid-activatable photodynamic therapy by protonation of the ionizable core, and significantly recruit tumor-infiltrating T lymphocytes for interferon gamma secretion, and thus sensitize the tumor cells to RSL-3-inducible ferroptosis. The combination of nanoparticle-induced ferroptosis and blockade of programmed death ligand 1 efficiently inhibits growth of B16-F10 melanoma tumor and lung metastasis of 4T1 breast tumors, suggesting the promising potential of ferroptosis induction for promoting cancer immunotherapy.
WOS关键词SUPPRESSION ; THERAPY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000665858200001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/309380]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China;
3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
推荐引用方式
GB/T 7714		 Song, Rundi,Li, Tianliang,Ye, Jiayi,et al. Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer[J]. ADVANCED MATERIALS,2021,33(31):2101155.
APA Song, Rundi.,Li, Tianliang.,Ye, Jiayi.,Sun, Fang.,Hou, Bo.,...&Yu, Haijun.(2021).Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer.ADVANCED MATERIALS,33(31),2101155.
MLA Song, Rundi,et al."Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer".ADVANCED MATERIALS 33.31(2021):2101155.

入库方式： OAI收割

来源：上海药物研究所

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