Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization
文献类型：期刊论文
| 作者 | Xiao, Ping1,2,3,4; Wang, Jue1,2,3,4; Fang, Lei1,2; Zhao, Zitong1,2; Sun, Xiangshi1,2; Liu, Xiaochen1,2,3,4; Cao, Haiqiang1,2,3; Zhang, Pengcheng1,2,3 ; Wang, Dangge1,2,3; Li, Yaping1,2,3,4,5,6
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2021-06-24 |
| 卷号 | 31期号:36页码:2104068 |
| 关键词 | adoptive cell transfer cancer immunotherapy dendritic cells nanovaccines neoantigens |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.202104068 |
| 文献子类 | Article |
| 英文摘要 | Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens' access to resident DCs and DCs' access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. |
| WOS关键词 | CANCER ; VACCINES ; NANOPARTICLES ; IMMUNOTHERAPY ; GROWTH |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000664995200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309381]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Dangge; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Medica, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Yantai Inst Mat Medica, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Bohai Rim Adv Res Inst Drug Discovery, Zhongshan 264000, Shandong, Peoples R China; 6.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Ping,Wang, Jue,Fang, Lei,et al. Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization[J]. ADVANCED FUNCTIONAL MATERIALS,2021,31(36):2104068. |
| APA | Xiao, Ping.,Wang, Jue.,Fang, Lei.,Zhao, Zitong.,Sun, Xiangshi.,...&Li, Yaping.(2021).Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization.ADVANCED FUNCTIONAL MATERIALS,31(36),2104068. |
| MLA | Xiao, Ping,et al."Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization".ADVANCED FUNCTIONAL MATERIALS 31.36(2021):2104068. |
入库方式： OAI收割
来源：上海药物研究所
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