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Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens

文献类型：期刊论文

作者Zheng, Yongzhe1,2,3; Ke, Chang-Qiang1,2; Zhou, Shuaizhen1,2; Feng, Lu1,2; Tang, Chunping1,2; Ye, Yang1,2,3,4
刊名FITOTERAPIA
出版日期2021-06
卷号151页码:104900
关键词Artemisia atrovirens Guaianolide TDDFT ECD calculation Cytotoxicity
ISSN号0367-326X
DOI10.1016/j.fitote.2021.104900
文献子类Article
英文摘要A phytochemical investigation of a medicinal plant Artemisia atrovirens was carried out, resulting in the characterization of a novel bis-nor seco-guaianolide, seco-atrovirenolide A (1), a new 1,10-seco-guaianolide derivative, seco-atrovirenoic acid A (2), and a new artifact 10-methanoyloxy-seco-atrovirenoic acid A (3), together with eight known guaianolide and seco-guaianolide derivatives (4-11). The structures of new compounds were fully established by extensive analysis of MS, 1D and 2D NMR spectroscopic data. The absolute configurations of the isolated compounds were confirmed by TDDFT ECD calculation, Mosher's method, and X-ray crystal diffraction experiment. All the compounds were tested in vitro for their cytotoxicity against HL-60 and A549 cell lines. Some of them showed moderate inhibitory activity against HL-60 cell lines with IC50 values ranging from 5.99 to 11.74 mu M.
WOS关键词SESQUITERPENE LACTONES ; ABSOLUTE-CONFIGURATIONS ; CONSTITUENTS ; ARGYI
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000663435300010
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/309392]  
专题新药研究国家重点实验室
通讯作者Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Medial, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Medial, Nat Prod Chem Dept, Shanghai 201203, Peoples R China;
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Zheng, Yongzhe,Ke, Chang-Qiang,Zhou, Shuaizhen,et al. Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens[J]. FITOTERAPIA,2021,151:104900.
APA Zheng, Yongzhe,Ke, Chang-Qiang,Zhou, Shuaizhen,Feng, Lu,Tang, Chunping,&Ye, Yang.(2021).Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens.FITOTERAPIA,151,104900.
MLA Zheng, Yongzhe,et al."Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens".FITOTERAPIA 151(2021):104900.

入库方式： OAI收割

来源：上海药物研究所

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