Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma
文献类型：期刊论文
| 作者 | Fu, Chen1,2; Yu, Zhaojin1,2; He, Ying1,3; Ding, Jian1,4 ; Wei, Minjie1,2,5
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| 刊名 | ONCOTARGETS AND THERAPY
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| 出版日期 | 2021-06-22 |
| 卷号 | 14页码:3861-3872 |
| 关键词 | SERPINA1 autophagy COAD prognostic relapse distant metastasis |
| ISSN号 | 1178-6930 |
| DOI | 10.2147/OTT.S306405 |
| 文献子类 | Article |
| 英文摘要 | Background: The relapse and distant metastasis in colon adenocarcinoma (COAD) patients with a poor prognosis. Autophagy has gained increasing attention recently. Methods: This study utilized univariate Cox analysis from the TCGA database to obtain 10 prognostic autophagy-related genes (ARGs). GO and KEGG functional annotation analysis suggested that the ARGs were significantly enriched in tumor metabolic processes. We verified the autophagy-related genes screened by TCGA clinical data. Then, we compared the expression of SERPINA1 in primary and metastatic tumor cells in the GEO database, and finally verified the relationship between SERPINA1 protein expression and prognosis with the CPTAC database. Results: The ROC curves showed SERPINA1 had robust prediction capability in judging the prognosis and disease process compared with the other 4 ARGs and risk score in COAD. Clinical relationship analysis further indicated SERPINA1 was related to TMN stage, clinical-stage, OS, RFS, and DMFS in COAD. Besides, survival analysis presented that higher expression of SERPINA1 was significantly associated with the longer OS, RFS, or DMFS. Moreover, SERPINA1 protein was validated to be associated with OS, RFS, and DMFS through our own IHC and CPTAC database. Finally, we exploratoryly combined the SERPINA1 mRNA and SERPINA1 protein as a new index for prognostics. Conclusion: This new combined index showed the highest prognostic value for OS, RFS, and DMFS, and had the potential to become a practical biomarker for prognosis. |
| WOS关键词 | CANCER STATISTICS ; R PACKAGE ; CELLS ; EXPRESSION ; APOPTOSIS ; PROTEINS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000664655100001 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309401]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian; Wei, Minjie |
| 作者单位 | 1.China Med Univ, Sch Pharm, Dept Pharmacol, Shenyang 110122, Peoples R China; 2.China Med Univ, Dept Pharmacol, Liaoning Key Lab Mol Targeted Antitumor Drug Dev, Shenyang 110122, Peoples R China; 3.China Med Univ, Affiliated Hosp 4, Dept Oncol, Shenyang 110000, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Liaoning Med Diag & Treatment Ctr, Shenyang 110000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Chen,Yu, Zhaojin,He, Ying,et al. Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma[J]. ONCOTARGETS AND THERAPY,2021,14:3861-3872. |
| APA | Fu, Chen,Yu, Zhaojin,He, Ying,Ding, Jian,&Wei, Minjie.(2021).Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma.ONCOTARGETS AND THERAPY,14,3861-3872. |
| MLA | Fu, Chen,et al."Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma".ONCOTARGETS AND THERAPY 14(2021):3861-3872. |
入库方式： OAI收割
来源：上海药物研究所
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