Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor
文献类型：期刊论文
| 作者 | Tan, Tao1; Wang, Yuqi1; Wang, Jing2; Wang, Zhiwan2; Wang, Hong2; Cao, Haiqiang2; Li, Jie2; Li, Yaping2,3 ; Zhang, Zhiwen2,3; Wang, Siling1
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| 刊名 | ACTA PHARMACEUTICA SINICA B
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| 出版日期 | 2020-02-27 |
| 卷号 | 10期号:3页码:529-545 |
| ISSN号 | 2211-3835 |
| 关键词 | Lipoprotein Drug delivery Tumor penetration Nanoparticles Cancer therapy |
| DOI | 10.1016/j.apsb.2019.05.006 |
| 文献子类 | Article |
| 英文摘要 | The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer therapy. Herein, we designed a targeting peptide-decorated biomimetic lipoprotein (termed as BL-RD) to enable their deep penetration and efficient accessibility to cancer cell fractions in a tumor, thereby improving the combinational chemophotodynamic therapy of triple negative breast cancer. BL-RD was composed of phospholipids, apolipoprotein A1 mimetic peptide (PK22), targeting peptide-conjugated cytotoxic mertansine (RM) and photodynamic agents of DiIC18(5) (DiD). The counterpart biomimetic lipoprotein system without RM (termed as BL-D) was fabricated as control. Both BL-D and BL-RD were nanometer-sized particles with a mean diameter of less than 30 nm and could be efficiently internalized by cancer cells. After intravenous injection, they can be specifically accumulated at tumor sites. When comparing to the counterpart BL-D, BL-RD displayed superior capability to permeate across the tumor mass, extravasate from tumor vasculature to distant regions and efficiently access the cancer cell fractions in a solid tumor, thus producing noticeable depression of the tumor growth. Taken together, BL-RD can be a promising delivery nanoplatform with prominent tumor-penetrating and cancer cells-accessing capability for effective tumor therapy. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; POLYMERIC MICELLES ; DRUG PENETRATION ; LUNG METASTASIS ; NANOPARTICLES ; MEMBRANE ; RELEASE ; MICROENVIRONMENT ; ACCUMULATION ; FIBROBLASTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| WOS记录号 | WOS:000518042300011 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309418]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping; Zhang, Zhiwen; Wang, Siling |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Tao,Wang, Yuqi,Wang, Jing,et al. Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor[J]. ACTA PHARMACEUTICA SINICA B,2020,10(3):529-545. |
| APA | Tan, Tao.,Wang, Yuqi.,Wang, Jing.,Wang, Zhiwan.,Wang, Hong.,...&Wang, Siling.(2020).Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor.ACTA PHARMACEUTICA SINICA B,10(3),529-545. |
| MLA | Tan, Tao,et al."Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor".ACTA PHARMACEUTICA SINICA B 10.3(2020):529-545. |
入库方式： OAI收割
来源：上海药物研究所
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