Ru(ii)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors
文献类型：期刊论文
| 作者 | Fu, Yangjie1,2; Wang, Zhaohui1,2; Zhang, Qiyu1,2; Li, Zhiyu1; Liu, Hong1,2 ; Bi, Xiaoling1; Wang, Jiang2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2020-02-12 |
| 卷号 | 10期号:11页码:6351-6355 |
| DOI | 10.1039/c9ra10749e |
| 文献子类 | Article |
| 英文摘要 | In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(ii) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy, and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility, and mechanistic studies were conducted. It offers a direct and efficient way to synthesize pyridone derivatives. |
| WOS关键词 | C3-SELECTIVE DIRECT ALKYLATION ; CATALYZED CROSS-COUPLINGS ; N-TOSYLHYDRAZONES ; DIAZO-COMPOUNDS ; DIRECT FUNCTIONALIZATION ; EFFICIENT SYNTHESIS ; ARYLATION ; 2-PYRIDONES ; PALLADIUM ; AMIDATION |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000515393300025 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309419]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Bi, Xiaoling; Wang, Jiang |
| 作者单位 | 1.China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, 24 Tongjiaxiang, Nanjing 210009, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Yangjie,Wang, Zhaohui,Zhang, Qiyu,et al. Ru(ii)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors[J]. RSC ADVANCES,2020,10(11):6351-6355. |
| APA | Fu, Yangjie.,Wang, Zhaohui.,Zhang, Qiyu.,Li, Zhiyu.,Liu, Hong.,...&Wang, Jiang.(2020).Ru(ii)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors.RSC ADVANCES,10(11),6351-6355. |
| MLA | Fu, Yangjie,et al."Ru(ii)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors".RSC ADVANCES 10.11(2020):6351-6355. |
入库方式： OAI收割
来源：上海药物研究所
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