Amphilectene Diterpene Isonitriles and Formamido Derivatives from the Hainan Nudibranch Phyllidia Coelestis
文献类型：期刊论文
| 作者 | Carbone, Marianna1; Ciavatta, Maria Letizia1; Manzo, Emiliano1; Li, Xiao-Lu2; Mollo, Ernesto1; Mudianta, I. Wayan3; Guo, Yue-Wei2 ; Gavagnin, Margherita1
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| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019-10-24 |
| 卷号 | 17期号:11页码:603 |
| 关键词 | nudibranch mollusks isonitrile diterpenes stereochemistry ecological activity |
| DOI | 10.3390/md17110603 |
| 文献子类 | Article |
| 英文摘要 | Terpene content of two distinct collections of the nudibranch Phyllidia coelestis from the South China Sea has been chemically analyzed. A series of amphilectene diterpenes, most likely of dietary origin, with isocyano and formamido functionalities have been isolated from both collections and spectroscopically characterized by an exhaustive nuclear magnetic resonance (NMR) analysis. Interestingly, the structural architecture of compounds 5-7 and 9 with both 8,13-cis and 12,13-cis ring junctions is unprecedented in the amphilectene skeleton. Metabolite 3, which was the most abundant in the nudibranch's mantle, has been shown to deter feeding by a generalist predator, supporting its involvement in chemical defense. |
| WOS关键词 | MARINE SPONGE ; ISOTHIOCYANATE AMPHILECTENES ; ANTIFOULING ACTIVITY ; ANTIMALARIAL ; ISOCYANIDES ; INHIBITION ; BIOSYNTHESIS ; ISOCYANATES ; METABOLITES ; TERPENOIDS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000502262200046 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309421]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Carbone, Marianna; Guo, Yue-Wei; Gavagnin, Margherita |
| 作者单位 | 1.CNR, ICB, Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Zuchongzhi Rd 555 Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Univ Pendidikan Ganesha, Study Program Chem Anal, Bali 81116, Indonesia |
| 推荐引用方式 GB/T 7714 | Carbone, Marianna,Ciavatta, Maria Letizia,Manzo, Emiliano,et al. Amphilectene Diterpene Isonitriles and Formamido Derivatives from the Hainan Nudibranch Phyllidia Coelestis[J]. MARINE DRUGS,2019,17(11):603. |
| APA | Carbone, Marianna.,Ciavatta, Maria Letizia.,Manzo, Emiliano.,Li, Xiao-Lu.,Mollo, Ernesto.,...&Gavagnin, Margherita.(2019).Amphilectene Diterpene Isonitriles and Formamido Derivatives from the Hainan Nudibranch Phyllidia Coelestis.MARINE DRUGS,17(11),603. |
| MLA | Carbone, Marianna,et al."Amphilectene Diterpene Isonitriles and Formamido Derivatives from the Hainan Nudibranch Phyllidia Coelestis".MARINE DRUGS 17.11(2019):603. |
入库方式： OAI收割
来源：上海药物研究所
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