Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients
文献类型：期刊论文
| 作者 | Mu, Xin1; Huang, Ou2; Jiang, Min3; Xie, Zuoquan4 ; Chen, Debo5; Zhang, Xi5
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| 刊名 | ONCOLOGY LETTERS
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| 出版日期 | 2019-05-17 |
| 卷号 | 18期号:1页码:742-750 |
| 关键词 | breast cancer ephrin B receptors prognosis Kaplan-Meier plotter hazard ratio |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2019.10363 |
| 文献子类 | Article |
| 英文摘要 | The roles of Ephrin B (EphB) receptors in cancer are relatively unknown as these receptors are associated with complex signaling pathways. A limited number of studies have investigated the association between EphB receptors and prognosis. Using the Kaplan-Meier plotter database, the present study investigated the associations between the mRNA expression levels of five EphB receptors and the outcomes of 3,554 patients with breast cancer who had been followed-up for 20 years. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated to assess the relative risk of survival. The results demonstrated that high mRNA expression levels of EphB2 (HR, 0.74; 95% CI, 0.66-0.84; P=2.1x10-6), EphB4 (HR, 0.82; 95% CI, 0.72-0.93; P=0.0023) and EphB6 (HR, 0.69; 95% CI, 0.61-0.78; P=3x10-9) were significantly associated with improved survival, while a high mRNA expression level of EphB3 (HR, 1.14; 95% CI, 1.01-1.28; P=0.029) was associated with worse survival for patients with breast cancer. High expression levels of all EphB receptors, including EphB1 (HR, 1.4; 95% CI, 1.02-1.94; P=0.039), EphB2 (HR, 1.34; 95% CI, 1.07-1.67; P=0.011), EphB3 (HR, 1.39; 95% CI, 1.11-1.73, P=0.0038), EphB4 (HR, 1.33; 95% CI, 1.06-1.67; P=0.013) and EphB6 (HR, 1.32; 95% CI, 1.05-1.65; P=0.016), were associated with an increased risk of mortality in patients with lymph-node-positive breast cancer. High mRNA expression levels of EphB1 were not associated with survival for all patients with breast cancer (HR, 0.85; 95% CI, 0.72-1.01; P=0.058). The results of the present suggested that EphB receptors may be useful as prognostic biomarkers of breast cancer. |
| WOS关键词 | TYROSINE KINASE ; EPHB4 RECEPTOR ; CELL-MIGRATION ; EXPRESSION ; ACTIVATION ; GROWTH ; PROLIFERATION ; MODULATION ; MECHANISMS ; INHIBITION |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000474896900086 |
| 出版者 | SPANDIDOS PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309428]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Xi |
| 作者单位 | 1.Fujian Med Univ, Affiliated Hosp 2, Dept Urol, Quanzhou 362000, Fujian, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Comprehens Breast Hlth Ctr, Shanghai 200025, Peoples R China; 3.Soochow Univ, Affiliated Hosp 1, Dept Oncol, Suzhou 215000, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 200025, Peoples R China; 5.Fujian Med Univ, Hosp Quanzhou 1, Dept Breast Oncol, Anji Rd, Quanzhou 362000, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mu, Xin,Huang, Ou,Jiang, Min,et al. Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients[J]. ONCOLOGY LETTERS,2019,18(1):742-750. |
| APA | Mu, Xin,Huang, Ou,Jiang, Min,Xie, Zuoquan,Chen, Debo,&Zhang, Xi.(2019).Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients.ONCOLOGY LETTERS,18(1),742-750. |
| MLA | Mu, Xin,et al."Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients".ONCOLOGY LETTERS 18.1(2019):742-750. |
入库方式： OAI收割
来源：上海药物研究所
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