Non-transition Metal-Mediated Diverse Aryl-Heteroatom Bond Formation of Arylammonium Salts
文献类型：期刊论文
| 作者 | Wang, Dong-Yu1,2; Wen, Xin1,2,3; Xiong, Chao-Dong1,2,3; Zhao, Jian-Nan1,2,4; Ding, Chun-Yong1,2,3 ; Meng, Qian1,2; Zhou, Hu1,2,3; Wang, Chao5,6; Uchiyama, Masanobu5,6; Lu, Xiao-Jie1,2,3
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| 刊名 | ISCIENCE
 |
| 出版日期 | 2019-05-31 |
| 卷号 | 15页码:307-315 |
| DOI | 10.1016/j.isci.2019.04.038 |
| 文献子类 | Article |
| 英文摘要 | Aryl-heteroatom (C-X) bonds ubiquitously exist in organic, medicinal, and material chemistry, but a universal method to construct diverse C-X bonds is lacking. Here we report our discovery of a convenient and efficient approach to construct various C-X bonds using arylammonium salts as the substrate via an SNAr process. This strategy features mild reaction condition, no request of transition metal catalyst, and easy formation of various C-X bonds (C-S, C-Si, C-Sn, C-Ge, C-Se, C-N). The method was successfully applied to a late-stage functionalization of an existing antibiotic drug, to a Clickable reaction of NBD-based ammonium salt as turn-on fluorescent probe to recognize L-cysteine and homocysteine, and to the synthesis of a DNA encoded library (DEL) bearing different C-X bonds. |
| WOS关键词 | CROSS-COUPLING REACTIONS ; NUCLEOPHILIC AROMATIC-SUBSTITUTION ; NI-CATALYZED STANNYLATION ; HALIDES ; SILYLATION ; IODIDES ; ACTIVATION ; AMINATION ; CHLORIDES ; CHEMISTRY |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000470104600027 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309432]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lu, Xiao-Jie; Zhang, Ao |
| 作者单位 | 1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 5.Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 6.RIKEN, Adv Elements Chem Lab, CPR, 2-1 Hirosawa, Wako, Saitama 3510198, Japan |
| 推荐引用方式 GB/T 7714 | Wang, Dong-Yu,Wen, Xin,Xiong, Chao-Dong,et al. Non-transition Metal-Mediated Diverse Aryl-Heteroatom Bond Formation of Arylammonium Salts[J]. ISCIENCE,2019,15:307-315. |
| APA | Wang, Dong-Yu.,Wen, Xin.,Xiong, Chao-Dong.,Zhao, Jian-Nan.,Ding, Chun-Yong.,...&Zhang, Ao.(2019).Non-transition Metal-Mediated Diverse Aryl-Heteroatom Bond Formation of Arylammonium Salts.ISCIENCE,15,307-315. |
| MLA | Wang, Dong-Yu,et al."Non-transition Metal-Mediated Diverse Aryl-Heteroatom Bond Formation of Arylammonium Salts".ISCIENCE 15(2019):307-315. |
入库方式： OAI收割
来源：上海药物研究所
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