Improving Cancer Vaccine Efficiency by Nanomedicine
文献类型：期刊论文
| 作者 | Cai, Junyu1,2,3; Wang, Hao3; Wang, Dangge1,2; Li, Yaping1,2
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| 刊名 | ADVANCED BIOSYSTEMS
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| 出版日期 | 2019-01-08 |
| 卷号 | 3期号:3页码:1800287 |
| 关键词 | adjuvants cancer immunotherapy cancer vaccines delivery systems nanomedicine |
| DOI | 10.1002/adbi.201800287 |
| 文献子类 | Review |
| 英文摘要 | Cancer vaccines, which have been widely investigated in the past few decades, are one of the most attractive strategies for cancer immunotherapy. Through the precise delivery of antigens and adjuvants to lymphoid organs or lymphocytes via nanotechnology, innate and adaptive immunity can be boosted to prevent the growth and relapse of malignant tumors. Indeed, nanomedicine offers great opportunities to improve the efficiency of vaccines. Various functional platforms are used to deliver small molecules, peptides, nucleic acids, and even whole cell antigens to the target area of interest, achieving enhanced antitumor immunity and durable therapeutic benefits. Herein, the recent progress in cancer vaccines based on nanotechnology is summarized. Novel platforms used for delivering tumor antigens, promoting adjuvant functions, and combining other therapeutic strategies are discussed. Moreover, possible striving directions and major challenges of nanomedicine for vaccination are also reviewed. |
| WOS关键词 | TOLL-LIKE RECEPTORS ; I CLINICAL-TRIAL ; CROSS-PRESENTATION ; DENDRITIC CELLS ; ANTITUMOR IMMUNITY ; LYMPH-NODE ; THERAPEUTIC VACCINES ; CHECKPOINT BLOCKADE ; INTERFERON-GAMMA ; SYSTEMIC IMMUNE |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000461872900004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309435]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Dangge; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.China State Inst Pharmaceut Ind, 285 Gebaini Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Junyu,Wang, Hao,Wang, Dangge,et al. Improving Cancer Vaccine Efficiency by Nanomedicine[J]. ADVANCED BIOSYSTEMS,2019,3(3):1800287. |
| APA | Cai, Junyu,Wang, Hao,Wang, Dangge,&Li, Yaping.(2019).Improving Cancer Vaccine Efficiency by Nanomedicine.ADVANCED BIOSYSTEMS,3(3),1800287. |
| MLA | Cai, Junyu,et al."Improving Cancer Vaccine Efficiency by Nanomedicine".ADVANCED BIOSYSTEMS 3.3(2019):1800287. |
入库方式： OAI收割
来源：上海药物研究所
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