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Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-β Plaques with Ultrasensitivity and High-Fidelity

文献类型：期刊论文

作者Fu, Wei1,2; Yan, Chenxu1,2; Guo, Zhiqian1,2; Zhang, Jingjing3; Zhang, Haiyan3; Tian, He1,2; Zhu, Wei-Hong1,2
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2019-02-20
卷号141期号:7页码:3171-3177
ISSN号0002-7863
DOI10.1021/jacs.8b12820
文献子类Article
英文摘要High-fidelity mapping of amyloid-beta (A beta) plaques is critical for the early detection of Alzheimer's disease. However, in vivo probing of A beta plaques by commercially available thioflavin derivatives (ThT or ThS) has proven to be extremely limited, as evident by the restriction of enrichment quenching effect, low signal-to-noise (S/N) ratio, and poor blood-brain barrier (BBB) penetrability. Herein, we demonstrate a rational design strategy of near-infrared (NIR) aggregation-induced emission (AIE)-active probes for A beta plaques, through introducing a lipophilic pi-conjugated thiophene-bridge for extension to NIR wavelength range with enhancement of BBB penetrability, and tuning the substituted position of the sulfonate group for guaranteeing specific hydrophilicity to maintain the fluorescence-off state before binding to A beta deposition. Probe QM-FN-SO3 has settled well the AIE dilemma between the lipophilic requirement for longer emission and aggregation behavior from water to protein fibrillogenesis, thus making a breakthrough in high-fidelity feedback on in vivo detection of A beta plaques with remarkable binding affinity, and serving as an efficient alternative to the commercial probe ThT or ThS.
WOS关键词ALZHEIMERS-DISEASE ; AMYLOID FIBRILS ; VIVO DETECTION ; THIOFLAVIN-T ; FLUORESCENCE PROBES ; PROGRESS ; TAU ; INHIBITION ; TRACKING ; LIGHT
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000459642000051
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/309436]  
专题新药研究国家重点实验室
通讯作者Guo, Zhiqian; Zhang, Haiyan; Zhu, Wei-Hong
作者单位1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;
2.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn,Shanghai Key Lab Funct Mat Ch, Feringa Nobel Prize Scientist Joint Res Ctr,Inst, Shanghai 200237, Peoples R China;
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Wei,Yan, Chenxu,Guo, Zhiqian,et al. Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-β Plaques with Ultrasensitivity and High-Fidelity[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019,141(7):3171-3177.
APA Fu, Wei.,Yan, Chenxu.,Guo, Zhiqian.,Zhang, Jingjing.,Zhang, Haiyan.,...&Zhu, Wei-Hong.(2019).Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-β Plaques with Ultrasensitivity and High-Fidelity.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,141(7),3171-3177.
MLA Fu, Wei,et al."Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-β Plaques with Ultrasensitivity and High-Fidelity".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 141.7(2019):3171-3177.

入库方式： OAI收割

来源：上海药物研究所

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