Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa
文献类型：期刊论文
| 作者 | Wu, Qihao1,2; Chen, Wen-Ting1; Li, Song-Wei1; Ye, Jian-Yu1; Huan, Xia-Juan1; Gavagnin, Margherita3; Yao, Li-Gong1; Wang, Hong2; Miao, Ze-Hong1; Li, Xu-Wen1
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019-01-16 |
| 卷号 | 17期号:1页码:56 |
| 关键词 | nitrogenous terpenoids South China Sea sponge nudibranch cytotoxicity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17010056 |
| 文献子类 | Article |
| 英文摘要 | A detailed chemical investigation of two South China Sea nudibranchs Phyllidiella pustulosa and Phyllidia coelestis, as well as their possible sponge-prey Acanthella cavernosa, led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid xidaoisocyanate A (1), one new naturally occurring nitrogen-containing kalihinane-type diterpenoid bisformamidokalihinol A (16), along with 17 known nitrogenous terpenoids (2-15, 17-19). The structures of all the isolates were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported axiriabiline A (5) was determined by X-ray diffraction (XRD) analysis. In a bioassay, the bisabolane-type sesquiterpenoids 8, 10, and 11 exhibited cytotoxicity against several human cancer cell lines. |
| WOS关键词 | MARINE SPONGE ; ISOQUINOLINEQUINONE ALKALOIDS ; ISOTHIOCYANATE SESQUITERPENES ; DITERPENE ISONITRILES ; ANTIMALARIAL ACTIVITY ; ANTIFOULING ACTIVITY ; JORUNNA-FUNEBRIS ; A-D ; AXINYSSA ; METABOLITES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000458053200056 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309439]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Zuchongzhi Rd,555 Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; 3.CNR, ICB, Via Campi Flegrei 34, I-80078 Pozzuoli, Na, Italy |
| 推荐引用方式 GB/T 7714 | Wu, Qihao,Chen, Wen-Ting,Li, Song-Wei,et al. Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa[J]. MARINE DRUGS,2019,17(1):56. |
| APA | Wu, Qihao.,Chen, Wen-Ting.,Li, Song-Wei.,Ye, Jian-Yu.,Huan, Xia-Juan.,...&Guo, Yue-Wei.(2019).Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa.MARINE DRUGS,17(1),56. |
| MLA | Wu, Qihao,et al."Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa".MARINE DRUGS 17.1(2019):56. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。