Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation
文献类型：期刊论文
| 作者 | Jiang, Jiaqi1,2; Yang, Junli1,2; Li, Siqi2; Yang, Yaxi2,4; Zhou, Bing1,2,3,4,5
|
| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2022-08-24 |
| 卷号 | 104期号:10页码:1792-1808 |
| DOI | 10.3987/COM-22-14722 |
| 英文摘要 | A Ru-catalyzed ortho C-H hydroxymethylation of 6-arylpurines has been developed. A wide range of functional groups were tolerated, providing the hydroxymethylated products in good or excellent yields using the readily available paraformaldehyde as a C1 synthon. Moreover, this protocol could be carried out in the presence of water and air, without stoichiometric undesirable waste under mild reaction conditions. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309444]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yaxi; Zhou, Bing |
| 作者单位 | 1.School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China 2.University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China 3.School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China 4.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China 5.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Jiang, Jiaqi,Yang, Junli,Li, Siqi,et al. Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation[J]. HETEROCYCLES,2022,104(10):1792-1808. |
| APA | Jiang, Jiaqi,Yang, Junli,Li, Siqi,Yang, Yaxi,&Zhou, Bing.(2022).Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation.HETEROCYCLES,104(10),1792-1808. |
| MLA | Jiang, Jiaqi,et al."Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation".HETEROCYCLES 104.10(2022):1792-1808. |
入库方式： OAI收割
来源：上海药物研究所
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