High-throughput screening and biological display technology: Applications in molecular imaging
文献类型:期刊论文
作者 | Luo, Renli1; Liu, Hongguang1; Cheng, Zhen2,3 |
刊名 | iRadiology |
出版日期 | 2023-03 |
卷号 | 1期号:1页码:18-35 |
DOI | 10.1002/ird3.11 |
文献子类 | Review |
英文摘要 | Molecular imaging plays important roles in many fields, including disease diagnosis, therapeutic efficacy evaluation, intraoperative imaging guidance, drug metabolism monitoring, and patient selection for appropriate treatment. As a key component, the targeting ligand determines the specificity, affinity, and in vivo performance of molecular imaging probes. In this review, high-throughput screening and biological display platforms for the discovery of ligands applicable to molecular imaging are briefly reviewed. Basic information on ligand development for molecular imaging is first introduced, followed by a presentation of various selection platforms and typical or iterative cases. The features, advantages, limitations, and application scope of screening and display platforms are compared and discussed. Last, a basic selection strategy and a perspective for protein-based ligands are provided. |
语种 | 英语 |
源URL | [http://119.78.100.183/handle/2S10ELR8/309608] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Liu, Hongguang; Cheng, Zhen |
作者单位 | 1.Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, China 2.State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China 3.Drug Discovery Shandong Laboratory, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, China |
推荐引用方式 GB/T 7714 | Luo, Renli,Liu, Hongguang,Cheng, Zhen. High-throughput screening and biological display technology: Applications in molecular imaging[J]. iRadiology,2023,1(1):18-35. |
APA | Luo, Renli,Liu, Hongguang,&Cheng, Zhen.(2023).High-throughput screening and biological display technology: Applications in molecular imaging.iRadiology,1(1),18-35. |
MLA | Luo, Renli,et al."High-throughput screening and biological display technology: Applications in molecular imaging".iRadiology 1.1(2023):18-35. |
入库方式: OAI收割
来源:上海药物研究所
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