Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics
文献类型：期刊论文
| 作者 | Peng, Liyuan1,2; Song, Ziping1,2; Zhao, Chengcheng1,2; Abuduwufuer, Kudusi1,2; Wang, Yanwen1,2; Wen, Zheng1,2; Ni, Li1,2; Li, Chenze1,2; Yu, Ying3; Zhu, Yi4 |
| 刊名 | Phenomics
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 3期号:1页码:34-49 |
| ISSN号 | 2730-5848 |
| DOI | 10.1007/s43657-022-00069-8 |
| 文献子类 | Article |
| 英文摘要 | Epoxyeicosatrienoic acids (EETs) have pleiotropic endogenous cardiovascular protective effects and can be hydrolyzed to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH). Heart failure with preserved ejection fraction (HFpEF) has shown an increased prevalence and worse prognosis over the decades. However, the role of sEH activity in HFpEF remains unclear. We enrolled 500 patients with HFpEF and 500 healthy controls between February 2010 and March 2016. Eight types of sEH-related eicosanoids were measured according to target metabolomics, and their correlation with clinical endpoints was also analyzed. The primary endpoint was cardiac mortality, and the secondary endpoint was a composite of cardiac events, including heart failure (HF) readmission, cardiogenic hospitalization, and all-cause mortality. Furthermore, the effect of sEH inhibitors on cardiac diastolic function in HFpEF was investigated in vivo and in vitro. Patients with HFpEF showed significantly enhanced EET degradation by the sEH enzyme compared with healthy controls. More importantly, sEH activity was positively correlated with cardiac mortality in patients with HFpEF, especially in older patients with arrhythmia. A consistent result was obtained in the multiple adjusted models. Decreased sEH activity by the sEH inhibitor showed a significant effective effect on the improvement of cardiac diastolic function by ameliorating lipid disorders in cardiomyocytes of HFpEF mouse model. This study demonstrated that increased sEH activity was associated with cardiac mortality in patients with HFpEF and suggested that sEH inhibition could be a promising therapeutic strategy to improve diastolic cardiac function. Clinical trial identifier: NCT03461107 (https://clinicaltrials.gov).Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-022-00069-8. |
| WOS关键词 | Eicosanoids ; Epoxyeicosatrienoic acids ; Heart failure with preserved ejection fraction ; Soluble epoxide hydrolase |
| 语种 | 英语 |
| WOS记录号 | MEDLINE: 36939801 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309620]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Chen; Zhang, Xu; Wang, Dao Wen |
| 作者单位 | 1.Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China. 2.Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, 430030 China. 3.Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070 China. 4.Tianjin Key Laboratory of Metabolic Diseases, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Center for Cardiovascular Diseases, Department of Physiology and Pathophysiology, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070 China. 5.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200032 China. 6.CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200032 China. 7.Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease-Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, 300070 China. |
| 推荐引用方式 GB/T 7714 | Peng, Liyuan,Song, Ziping,Zhao, Chengcheng,et al. Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics[J]. Phenomics,2023,3(1):34-49. |
| APA | Peng, Liyuan.,Song, Ziping.,Zhao, Chengcheng.,Abuduwufuer, Kudusi.,Wang, Yanwen.,...&Wang, Dao Wen.(2023).Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics.Phenomics,3(1),34-49. |
| MLA | Peng, Liyuan,et al."Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics".Phenomics 3.1(2023):34-49. |
入库方式： OAI收割
来源：上海药物研究所
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