Chapter Nine - Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery
文献类型：专著章节
| 作者 | Wu, Xinyu1,2; Xie, Yanqiu1,2; Zhao, Kehao1; Lu, Jing1 |
| 发表日期 | 2023-01-10 |
| 出处 | Advances in Cancer Research |
| 出版地 | England |
| 出版者 | Elsevier |
| 页码 | 387-421 |
| WOS记录号 | MEDLINE: 36990537 |
| 英文摘要 | Oncogenic transcription activation is associated with tumor development and resistance derived from chemotherapy or target therapy. The super elongation complex (SEC) is an important complex regulating gene transcription and expression in metazoans closely related to physiological activities. In normal transcriptional regulation, SEC can trigger promoter escape, limit proteolytic degradation of transcription elongation factors and increase the synthesis of RNA polymerase II (POL II), and regulate many normal human genes to stimulate RNA elongation. Dysregulation of SEC accompanied by multiple transcription factors in cancer promotes rapid transcription of oncogenes and induce cancer development. In this review, we summarized recent progress in understanding the mechanisms of SEC in regulating normal transcription, and importantly its roles in cancer development. We also highlighted the discovery of SEC complex target related inhibitors and their potential applications in cancer treatment. |
| DOI标识 | 10.1016/bs.acr.2022.12.007 |
| 语种 | 英语 |
| WOS关键词 | Cancer ; Epigenetics ; Small molecular inhibitor ; Super elongation complex ; Transcription elongation |
| 卷号 | 158 |
| 文献子类 | Review |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309621]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, 2.Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Wu, Xinyu,Xie, Yanqiu,Zhao, Kehao,et al. Chapter Nine - Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery. England:Elsevier,2023:387-421. |
入库方式： OAI收割
来源：上海药物研究所
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