Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia
文献类型：期刊论文
| 作者 | Huang, Bingjie3,4,5,6; Pu, Chengcheng3,4,5,6; Guo, Xiaodong3,4,5,6 ; Chan, Raymond C. K.1,2; Huang, Jia1,2; Yu, Xin3,4,5,6
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| 刊名 | ASIAN JOURNAL OF PSYCHIATRY
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| 出版日期 | 2024-02-01 |
| 卷号 | 92页码:6 |
| ISSN号 | 1876-2018 |
| 关键词 | First episode schizophrenia Humor processing Functional magnetic resonance imaging |
| DOI | 10.1016/j.ajp.2023.103892 |
| 通讯作者 | Huang, Jia(huangj@psych.ac.cn) ; Yu, Xin(yuxin@bjmu.edu.cn) |
| 英文摘要 | Background: Patients with schizophrenia present difficulties in humor recognition and appreciation, but the neural mechanism of these deficits remains unclear. This study aimed to elucidate neural substrates underlying humor processing in patients with first episode schizophrenia (FES). Methods: This study recruited 40 patients with FES (illness duration <= 4 years) and 31 healthy controls matching for age, gender and education level. Participants completed a fMRI verbal humor processing paradigm comprising 96 stories, half for funny punch-line condition and the other half for unfunny condition. Participants were required to judge whether the story was funny or not. Signal detection theory (SDT) analysis was used to calculate d' and beta values which represented sensitivity and inner criteria for humor signals respectively. The funny-unfunny contrast was analyzed to identify the brain regions related with humor processing. d' and beta values were put into the imaging regression analysis. Results: Patients with FES showed significantly lower hit rate and sensitivity of humor signals (d'). At the neural level, patients with FES hypo-activated in ventral medial prefrontal cortex (vmPFC) and anterior cingulate cortex (ACC) while hyper-activated in middle temporal gyrus (MTG) and superior temporal gyrus (STG) compared to controls. In addition, activity in vmPFC and ACC was positively associated with d' and beta values, while activity in STG was positively associated with beta values in the clinical group. Conclusions: Patients with FES exhibited decreased sensitivity to humor signals. Hypo-activation in frontal re-gions and hyper-activation in temporal regions were associated with the humor processing deficits. |
| 收录类别 | SCI |
| WOS关键词 | ANTERIOR CINGULATE CORTEX ; COGNITIVE CONTROL ; SOCIAL COGNITION ; NEURAL CIRCUIT ; VERBAL JOKES ; EMOTION ; COMPREHENSION ; DEFICITS ; FMRI ; APPRECIATION |
| 资助项目 | National Science Fund China[82171500] ; Key Program of Beijing Science and Technology Commission[D171100007017002] ; Capital's Funds for Health Improvement and Research (CFH)[2018-4-4116] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001165863800001 |
| 资助机构 | National Science Fund China ; Key Program of Beijing Science and Technology Commission ; Capital's Funds for Health Improvement and Research (CFH) |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47278]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Huang, Jia; Yu, Xin |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 4.Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China 5.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China 6.Peking Univ Sixth Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Bingjie,Pu, Chengcheng,Guo, Xiaodong,et al. Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2024,92:6. |
| APA | Huang, Bingjie,Pu, Chengcheng,Guo, Xiaodong,Chan, Raymond C. K.,Huang, Jia,&Yu, Xin.(2024).Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,92,6. |
| MLA | Huang, Bingjie,et al."Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 92(2024):6. |
入库方式： OAI收割
来源：心理研究所
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